Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
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Summary
The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors in the Xenopus gastrula.
- Type
- article
- Published
- 1997-03-21
- Cited by
- 766
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969910714
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16753922
Keywords
Biology, Wnt signaling pathway, Cell biology, Signal transduction, Antagonist
References
- Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.
- Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma.
- Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.
- Transient expression of XMyoD in non-somitic mesoderm of Xenopus gastrulae.
- Secretory and inductive properties of Drosophila wingless protein in Xenopus oocytes and embryos.
- Analysis of Dishevelled signalling pathways during Xenopus development.
- The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
- Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.
- Injected Wnt RNA induces a complete body axis in Xenopus embryos.
- Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
- A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled(*)
- A common plan for dorsoventral patterning in Bilateria
- Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.
- Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.
- The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.
- Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
- A new member of the frizzled family from Drosophila functions as a Wingless receptor
- Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila
- Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.
- Wnt genes and vertebrate development.
Cited by
- Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart*
- Inhibition of Wnt Signaling by Exogenous Mfrzbl Protein Affects Molar Tooth Size
- Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules*
- Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
- Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro.
- Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State
- Continuity and change: paradigm shifts in neural induction.
- Signaling pathways and preimplantation development of mammalian embryos
- WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
- Wnt Secretion and Gradient Formation
- Regional Specification of the Xenopus Lateral Plate Mesoderm
- Making senses development of vertebrate cranial placodes.
- Pieter Nieuwkoop's contributions to the understanding of meso-endoderm induction and neural induction in chordate development.
- A gust of WNT: analysis of the canonical WNT pathway.
- Wnt signaling in osteosarcoma.
- The role of the homeodomain protein Bozozok in zebrafish axis formation.
- Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.
- Establishment of retinoic acid gradients in the early development of Xenopus laevis
- A T-box Protein Interacting with the TCF Transcriptional Switch of Wnt Signaling in Xenopus Dorsal Axis Development.
- The role of Wnt signalling in synapse maintenance in the hippocampus
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