Robust Optimal Design for the Estimation of Hyperparameters in Population Pharmacokinetics
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Summary
The expectation of the determinant of the inverse of the population Fisher information matrix is proposed as a criterion to evaluate and optimize designs for the estimation of population pharmacokinetic (PK) parameters.
- Type
- article
- Published
- 1998-12-01
- Cited by
- 57
- References
- 27
- OpenAlex
- https://openalex.org/W1566325672
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8046064
Keywords
Mathematics, Statistics, Population, Prior probability, Sampling (signal processing)
References
- Comparison of ED, EID, and API Criteria for the Robust Optimization of Sampling Times in Pharmacokinetics
- Experimental Design and Efficient Parameter Estimation in Preclinical Pharmacokinetic Studies
- Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics*
- Modelling of individual pharmacokinetics for computer-aided drug dosage.
- Accelerated Stochastic Approximation
- Implementation of OSPOP, an algorithm for the estimation of optimal sampling times in pharmacokinetics by the ED, EID and API criteria.
- Incorporating prior parameter uncertainty in the design of sampling schedules for pharmacokinetic parameter estimation experiments.
- A Numerical Procedure to Generate a Sample Covariance Matrix
- The Use of Population Pharmacokinetics in Drug Development
- 31 Optimal design in nonlinear regression random effects models — application in population pharmacokinetics
- Qualitative and quantitative experiment design for phenomenological models - A survey
- Robust experiment design via stochastic approximation
- Robust experiment design via maximin optimization
- Experimental design and efficient parameter estimation in population pharmacokinetics
- Comparison of some practical sampling strategies for population pharmacokinetic studies
- Bayesian Parameter Estimation and Population Pharmacokinetics
- The Equivalence of Two Extremum Problems
- A computationally efficient approach for the design of population pharmacokinetic studies
- Optimal sampling times for pharmacokinetic experiments
- Population pharmacokinetics/dynamics.
Cited by
- The use of simulated annealing for finding optimal population designs
- Simultaneous optimal experimental design on dose and sample times
- Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design
- Impact of Pharmacokinetic–Pharmacodynamic Model Linearization on the Accuracy of Population Information Matrix and Optimal Design
- Population Pharmacokinetic Analysis and Optimization of the Experimental Design for Mizolastine Solution in Children
- Optimal experimental designs for hyperparameter estimation in hierarchical linear models
- Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine
- Population PK/PD解析を用いた評価法
- Sample reuse simulation in optimal design for Tmax in pharmacokinetic experiments
- Robust Population Pharmacokinetic Experiment Design
- Optimal sampling times in bioequivalence studies using a simulated annealing algorithm
- Critical Considerations about Clinical Trials Simulation
- Evaluation of Uncertainty Parameters Estimated by Different Population PK Software and Methods
- The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments
- D‐optimal designs for parameter estimation for indirect pharmacodynamic response models
- Design of population pharmacokinetic experiments using prior information.
- A program for the optimum design of pharmacokinetic, pharmacodynamic, drug metabolism and drug-drug interaction models
- OPTIMUM DESIGN OF SAMPLING TIMES FOR INFERENCE OF COMPARTMENT MODELS BASED ON CURVATURE
- Sample Size Computations for PK/PD Population Models
- Pharmacokinetic-pharmacodynamic modeling of the effect of triamcinolone acetonide on central macular thickness in patients with diabetic macular edema.
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