Simultaneous optimal experimental design on dose and sample times
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Summary
Three different PK–PD models where considered and in most of the cases the optimization method did change the optimal design and furthermore the precision was improved with the simultaneous approach.
- Type
- article
- Published
- 2009-03-25
- Cited by
- 43
- References
- 24
- OpenAlex
- https://openalex.org/W19319484
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9806644
Keywords
Medicine
References
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- Robust experiment design via stochastic approximation
- Optimal Design for Model Discrimination and Parameter Estimation for Itraconazole Population Pharmacokinetics in Cystic Fibrosis Patients
- Computation of the explicit solution to the Michaelis-Menten equation
- Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs
- Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics
- Using Disease Progression Models as a Tool to Detect Drug Effect
- Bayesian Optimal Designs for Pharmacokinetic Models: Sensitivity to Uncertainty
- Optimal design in random-effects regression models
- Derivation of various NONMEM estimation methods
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- Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design
- Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications
- Faster Optimal Design Calculations for Practical Applications
- Model-based evaluation of drug-induced QTc prolongation for compounds in early development.
- Optimal sampling of antipsychotic medicines: a pharmacometric approach for clinical practice.
- Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
- PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool
- Optimised protocol design for the screening of analgesic compounds in neuropathic pain
- Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain
- D-optimal designs for parameter estimation for indirect pharmacodynamic response models
- Influence of Covariance Between Random Effects in Design for Nonlinear Mixed-Effect Models with an Illustration in Pediatric Pharmacokinetics
- Optimal Sampling Scheme for Estimation of Intraocular Pressure Diurnal Curves in Glaucoma Trials
- Trial Treatment Length Optimization With an Emphasis on Disease Progression Studies
- A general model-based design of experiments approach to achieve practical identifiability of pharmacokinetic and pharmacodynamic models
- Ethically Attractive Dose‐Finding Designs for Drugs With a Narrow Therapeutic Index
- Simultaneous optimal experimental design for in vitro binding parameter estimation
- Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin
- Optimal Design in Population Kinetic Experiments by Set-Valued Methods
- Model‐based design of experiments for cellular processes
- Adaptive‐Optimal Design in PET Occupancy Studies
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