Two modes of exocytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B
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Summary
Results show that exocytosis from synaptosomes has a phosphatase‐sensitive and phosphatases‐insensitive component, and that there are two modes of phosphat enzyme‐sensitive exocyTosis that can be elicited by different depolarization conditions.
- Type
- article
- Published
- 2003-06-01
- Cited by
- 43
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1547425048
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22731412
Keywords
Exocytosis, Depolarization, Phosphatase, Okadaic acid, Synaptosome
References
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- Multiple effects of phorbol esters in the rat spinal dorsal horn
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- Calmodulin and Protein Kinase C Increase Ca2+-stimulated Secretion by Modulating Membrane-attached Exocytic Machinery*
- Release of secretory products during transient vesicle fusion
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- Mathematical models of protein kinase signal transduction.
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- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.
- Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals
- Okadaic acid and cyclosporin A modulate [(3)H]GABA release from rat brain synaptosomes.
- Protein Phosphorylation and Calcium Uptake into Rat Forebrain Synaptosomes: Modulation by the σ Ligand, 1,3‐Ditolylguanidine
- Two Mechanisms of Synaptic Vesicle Recycling in Rat Brain Nerve Terminals
- Synaptosomes possess an exocytotic pool of glutamate
- An Ion Channel Locus for the Protein Kinase C Potentiation of Transmitter Glutamate Release from Guinea Pig Cerebrocortical Synaptosomes
- Protein kinase C potentiates transmitter release from the chick ciliary presynaptic terminal by increasing the exocytotic fusion probability
Cited by
- Protein phosphatase‐1M and Rho‐kinase affect exocytosis from cortical synaptosomes and influence neurotransmission at a glutamatergic giant synapse of the rat auditory system
- A new function for glycine GlyT2 transporters: Stimulation of γ‐aminobutyric acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca2+‐dependent anion channels
- Aspartate release from rat hippocampal synaptosomes.
- The role of serine/threonine protein phosphatases in exocytosis.
- Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.
- Osthole or imperatorin‐mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings
- Influence of Hypotonic Shock on Glutamate and GABA Uptake in Rat Brain Synaptosomes
- Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets.
- Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization
- Protein phosphatase 2A dephosphorylates SNAP-25 through two distinct mechanisms in mouse brain synaptosomes.
- Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.
- Mast cell function: regulation of degranulation by serine/threonine phosphatases.
- Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals.
- Cellular mechanisms of acute decrease of glutamate release induced by raloxifene in rat cerebral cortex.
- Calcineurin in memory and bidirectional plasticity.
- Impact of Actin Filament Stabilization on Adult Hippocampal and Olfactory Bulb Neurogenesis
- Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: an NMDA receptor-independent mechanism.
- Calcineurin regulation of neuronal plasticity.
- Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan.
- Pyridoxine Inhibits Depolarization-Evoked Glutamate Release in Nerve Terminals from Rat Cerebral Cortex: a Possible Neuroprotective Mechanism?
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