Protein Phosphorylation and Calcium Uptake into Rat Forebrain Synaptosomes: Modulation by the σ Ligand, 1,3‐Ditolylguanidine
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Summary
Data suggest that DTG was producing some of its effects on synapsin I and dynamin phosphorylation and intrasynaptosomal Ca2+ levels via inhibition of N‐type Ca2+, and not via downstream regulation of cyclic GMP levels.
- Type
- article
- Published
- 1997-05-01
- Cited by
- 39
- References
- 42
- OpenAlex
- https://openalex.org/W2007062754
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41641871
Keywords
Chemistry, Depolarization, Sodium nitroprusside, Calcium, Protein kinase C
References
- Depolarization-dependent protein phosphorylation in synaptosomes: mechanisms and significance.
- Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells
- Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons.
- Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.
- Opipramol, a potent sigma ligand, is an anti-ischemic agent: neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements.
- Nitric oxide stimulates Ca(2+)-independent synaptic vesicle release.
- Haloperidol and reduced haloperidol-induced exacerbation of the dystonia produced by the kappa opioid U50,488H in guinea-pigs is associated with inhibition of sigma binding sites: behavioural and autoradiographical studies.
- Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: modulation by sigma (σ) receptor ligands
- Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
- A proposal for the classification of sigma binding sites.
- Cyclic GMP depresses hippocampal Ca2+ current through a mechanism independent of cGMP-dependent protein kinase.
- The bioenergetics of neurotransmitter release.
- Interactions between NMDA/Nitric oxide systems and σ receptors in learning and memory in mice
- Haloperidol blocks voltage-activated Ca2+ channels in hippocampal neurones.
- Differential Activities of Protein Phosphatase Types 1 and 2A in Cytosolic and Participate Fractions from Rat Forebrain
- Sigma receptor regulation of norepinephrine release from rat hippocampal slices.
- Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures.
- Blockade by sigma site ligands of high voltage‐activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones
- Exocytotic Ca2+ channels in mammalian central neurons.
- A rapid method for isolation of synaptosomes on Percoll gradients.
Cited by
- Rôle des mitochondries dans la régulation des oscillations de calcium des hépatocytes : approches expérimentale et computationnelle
- N-methyl-D-aspartate (NMDA) and sigma receptor antagonism as neuroprotective strategy for polycyclic amines
- Sigma receptors modulation of voltage-gated ion channels in rat autonomic neurons
- Two modes of exocytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B
- Sigma receptors [σRs]: biology in normal and diseased states
- Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
- Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities.
- σ Receptors: potential medications development target for anti-cocaine agents
- The antidepressant-like effect induced by the sigma1 (σ1) receptor agonist igmesine involves modulation of intracellular calcium mobilization
- Neurosteroids Enhance Spontaneous Glutamate Release in Hippocampal Neurons
- Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.
- Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes.
- Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor.
- Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation.
- Review of the pharmacological and clinical profile of rimcazole.
- Regulating ankyrin dynamics: Roles of sigma-1 receptors.
- Membrane‐delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP
- Effects of σ1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats
- Sigma‐1 receptor as regulator of neuronal intracellular Ca2+: clinical and therapeutic relevance
- The role of sigma receptors in depression.
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