Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
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Summary
A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.
- Type
- article
- Published
- 2008-06-12
- Cited by
- 7,294
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1526927233
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205090068
Keywords
Medicine, Hazard ratio, Glycated hemoglobin, Internal medicine, Type 2 diabetes
References
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- Design of the cooperative study on glycemic control and complications in diabetes mellitus type 2: Veterans Affairs Diabetes Trial.
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- Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
- Increasing Cardiovascular Disease Burden Due to Diabetes Mellitus: The Framingham Heart Study
- Forearm vascular reactivity is differentially influenced by gliclazide and glibenclamide in chronically treated type 2 diabetic patients
- Cause-specific mortality in a population-based study of diabetes.
- Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.
- Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: Meta-analysis of randomized trials.
- Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals.
- The association of glycemia and cause-specific mortality in a diabetic population.
- Meta-Analysis: Glycosylated Hemoglobin and Cardiovascular Disease in Diabetes Mellitus
- Gliclazide improves anti‐oxidant status and nitric oxide‐mediated vasodilation in Type 2 diabetes
- Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.
- Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.
- Effect of a multifactorial intervention on mortality in type 2 diabetes.
- 10-year follow-up of intensive glucose control in type 2 diabetes.
- Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
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- Glucose control and cardiovascular outcomes in individuals with diabetes mellitus: lessons learned from the megatrials.
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- Aspirin for primary prevention of cardiovascular events in diabetes: still an open question.
- Hypoglycemic pharmacological treatment of type 2 diabetes: targeting the endothelium.
- Clinical trials: evidence based and clinically relevant or not?
- Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use.
- Intensive Glucose-Lowering Therapy Reduces Cardiovascular Disease Events in Veterans Affairs Diabetes Trial Participants With Lower Calcified Coronary Atherosclerosis
- Comparison of incidence of acute myocardial infarction in patients with type 2 diabetes mellitus following initiation of neutral protamine Hagedorn insulin versus insulin glargine.
- Position statement of the Australian Diabetes Society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus
- Residual microvascular risk in diabetes: unmet needs and future directions
- The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.
- Introduction to the Second World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
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