Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza
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Summary
It is shown that upon in vitro exposure to influenza,NKp46 expression on NK cells decreases, whereas expression of 2B4, an activating receptor that can enhance natural cytotoxicity in synergy with NKp46, is up‐regulated, and this suggests that NK p46 may play an important role in the innate immune response to human influenza.
- Type
- article
- Published
- 2011-04-01
- Cited by
- 43
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W1518435779
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19971976
Keywords
Interleukin 12, Natural killer cell, Natural (archaeology), Immunology, Biology
References
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- Influenza A Vaccine Based on the Extracellular Domain of M2: Weak Protection Mediated via Antibody-Dependent NK Cell Activity
- Cytotoxic T cells.
- Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
- T cell-dependent production of IFN-gamma by NK cells in response to influenza A virus.
- Regulation of 2B4 (CD244)‐mediated NK cell activation by ligand‐induced receptor modulation
- Human natural killer cell receptor 2B4 (CD244) down-regulates its own expression by reduced promoter activity at an Ets element.
- Evolutionary struggles between NK cells and viruses
- Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors.
- 2B4, a new member of the immunoglobulin gene superfamily, is expressed on murine dendritic epidermal T cells and plays a functional role in their killing of skin tumors.
- The Functional Impairment of Natural Killer cells during Influenza Virus Infection
- CD107a as a functional marker for the identification of natural killer cell activity.
- 2B4 functions as a co‐receptor in human NK cell activation
- Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections
- Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion.
- Role of natural killer cells in the generation of influenza virus-specific cytotoxic T cells.
Cited by
- Mechanism of natural killer cell mediated T cell cycle arrest during human parainfluenza virus type 3 infection
- Sweet Is the Memory of Past Troubles: NK Cells Remember.
- Identification of anti-inflammatory constituents in Hypericum species and unveiling the underlying mechanism in LPS-stimulated mouse macrophages and H1N1 influenza virus infected BALB/c mouse
- Role of Ly49 Receptors on Natural Killer Cells During Influenza Virus Infection
- Characterisation of CD8neg and CD8+ human natural killer cell subsets
- Natural killer cells: walking three paths down memory lane.
- Changes in Cytokine Levels and NK Cell Activation Associated with Influenza
- Evolving role of 2B4/CD244 in T and NK cell responses during virus infection
- RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.
- Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy
- Early Responses of Natural Killer Cells in Pigs Experimentally Infected with 2009 Pandemic H1N1 Influenza A Virus
- Influenza Vaccine Induces Intracellular Immune Memory of Human NK Cells
- Obstacles to ideal anti-HIV antibody-dependent cellular cytotoxicity responses.
- Porcine CD8αdim/-NKp46high NK cells are in a highly activated state
- Clinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell Transplantation
- Effect of influenza A infection on umbilical cord blood natural killer function regulation with interleukin-15.
- Anti-HIV Antibody–Dependent Activation of NK Cells Impairs NKp46 Expression
- NK cells exacerbate the pathology of influenza virus infection in mice
- Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry
- Influenza Virus Infection but Not H1N1 Influenza Virus Immunization Is Associated with Changes in Peripheral Blood NK Cell Subset Levels
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