Design and analysis of experiments on mutagenicity. I. Minimal sample sizes.
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Summary
It is found that the best designed (most powerful) experiments are those with approximately equal numbers of indviduals in the experimental and control groups, and those experiments in which excess numbers of individuals are allotted to either the experimental or control groups suffer a substantial reduction in power.
- Type
- article
- Published
- 1978-06-01
- Cited by
- 19
- References
- 7
- OpenAlex
- https://openalex.org/W1515035037
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5676882
Keywords
Computational biology, Biology
References
- Simplified Method for Testing Mutagens in Saccharomyces
- Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
- Comments on tests of dominant lethals in mice.
- Tables for determining the statistical significance of mutation frequencies.
- Probability models and statistical methods in genetics
- Statistical problems connected with the sex-linked recessive lethal test in Drosophila melanogaster. I. The use of the Kastenbaum-Bowman test.
- Probability models and statistical methods in genetics
- Probability Models and Statistical Methods in Genetics
- Measurement of Recessive Lethal Damage Over the Entire Genome and at Two Specific Loci in the ad-3 Region of a Two-Component Heterokaryon of Neurospora crassa
Cited by
- An evaluation of the genotoxic properties of insecticides following plant and animal activation.
- Design and analysis of experiments on mutagenicity. II. Assays involving microorganisms.
- The detection of mutants in mice by electrophoresis: results of a model induction experiment with procarbazine.
- The Ames Salmonella/microsome mutagenicity assay.
- Significance testing in mutagen screening: the dependence of statistical power on the control sample size.
- Chromium genotoxicity as influenced by complexation and rate effects.
- Promutagen activation in parasite-infected organisms: preliminary observations with Fasciola hepatica-infected mice and aflatoxin B1.
- Ambient air pollutants: collection, chemical characterization and mutagenicity testing.
- Mouse spermatogonia exposed to a high, multiply fractionated dose of a cancer chemotherapeutic drug: mutation analysis by electrophoresis.
- Quantitative forward-mutation specificity of mono-functional alkylating agents, ICR-191, and aflatoxin B1 in mouse lymphoma cells.
- A method for determining the statistical significance of mutation frequencies
- Ontogeny of the barley plant as related to mutation expression and detection of pollen mutations.
- Genotoxic properties of 2,4,7-trinitro-9-fluorenone.
- Promutagen activation in partially hepatectomized mice.
- Mutagenicity of a series of hexacoordinate rhodium(III) compounds.
- Assessment of the mutagenicity of fractions from s-triazine-treated Zea mays.
- Plant dependent mutation assays.
- Mutagenicity of sangak bread with emphasis on gasoline as a burning fuel
- Data Analysis Applications in Toxicology
- The Activation of Chemicals into Mutagens by Green Plants
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