Diagnostic Peptide Discovery: Prioritization of Pathogen Diagnostic Markers Using Multiple Features
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Summary
A computational method to assess a defined set of molecular properties for each potential diagnostic target in a reference genome is described and applied to the identification of candidate diagnostic peptides in the protozoan Trypanosoma cruzi, the causative agent of Chagas disease.
- Type
- article
- Published
- 2012-12-14
- Cited by
- 39
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013106815
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7851200
Keywords
Computational biology, Proteome, Biology, Epitope, Genome
References
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Cited by
- The helminth parasite proteome at the host-parasite interface - Informing diagnosis and control.
- Peptidomics in veterinary science: focus on bovine paratuberculosis
- Secondary Structure Determination of Peptides and Proteins After Immobilization.
- Rapid Identification of Novel Immunodominant Proteins and Characterization of a Specific Linear Epitope of Campylobacter jejuni
- Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment
- Computational Models for Neglected Diseases: Gaps and Opportunities
- Improving Serodiagnosis of Human and Canine Leishmaniasis with Recombinant Leishmania braziliensis Cathepsin L-like Protein and a Synthetic Peptide Containing Its Linear B-cell Epitope
- Identification of Strain-Specific B-cell Epitopes in Trypanosoma cruzi Using Genome-Scale Epitope Prediction and High-Throughput Immunoscreening with Peptide Arrays
- Epitope Mapping of the HSP83.1 Protein of Leishmania braziliensis Discloses Novel Targets for Immunodiagnosis of Tegumentary and Visceral Clinical Forms of Leishmaniasis
- Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants
- Sensing parasites: Proteomic and advanced bio-detection alternatives.
- Molecular Validation of Putative Antimicrobial Peptides for Improved HumanImmunodeficiency Virus Diagnostics via HIV Protein p24
- Combinatorial Library Screening Coupled to Mass Spectrometry to Identify Valuable Cyclic Peptides
- Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome
- Sensitive fluorescent imaging of Salmonella enteritidis and Salmonella typhimurium using a polyvalent directed peptide polymer
- Chagas disease diagnostic applications: present knowledge and future steps
- Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes
- Novel biotechnological platform based on baculovirus occlusion bodies carrying Babesia bovis small antigenic peptides for the design of a diagnostic enzyme-linked immunosorbent assay (ELISA)
- A comparative in silico linear B-cell epitope prediction and characterization for South American and African Trypanosoma vivax strains.
- Cs1, a Clonorchis sinensis-derived serodiagnostic antigen containing tandem repeats and a signal peptide
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