Cellular Mechanisms of Oxidative Stress and Action in Melanoma
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Summary
Current evidence about the role of oxidative stress in melanoma initiation and progression, the mechanisms by which ROS influence the DNA methylation pattern of transformed melanocytes, and the employment of this epimutation as a biomarker for melanoma diagnosis, prognosis, and drug resistance evaluation are reviewed.
- Type
- review
- Published
- 2015-05-06
- Cited by
- 102
- References
- 150
- Access
- Open access
- OpenAlex
- https://openalex.org/W1514882132
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15438981
Keywords
Oxidative stress, Epigenetics, DNA methylation, Melanoma, Cancer research
References
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- Sun Exposure, Sunbeds and Sunscreens and Melanoma. What Are the Controversies?
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- Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis Special Issue: DNA Repair and Genetic Instability
- Ultraviolet damage, DNA repair and vitamin D in nonmelanoma skin cancer and in malignant melanoma: an update.
- Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
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- Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
- H2O2 and antioxidants have opposite effects on activation of NF‐kappa B and AP‐1 in intact cells: AP‐1 as secondary antioxidant‐responsive factor.
- DNA Methylation Profiling Distinguishes Malignant Melanomas from Benign Nevi
- Hematopoietic growth factors signal through the formation of reactive oxygen species.
- Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
- Correlation between melanogenic and catalase activity in in vitro human melanocytes: a synergic strategy against oxidative stress
- Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP.
Cited by
- Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models
- Current trends in the treatment of malignant melanoma.
- ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
- Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review
- Investigation of the cytotoxic implications of metal chelators against melanoma and approaches to improve the cytotoxicity profiles of metal coordinating agents
- High Doses of Ascorbate (Vitamin C): A New Frontier in the Treatment of Intraocular Cancer
- Radical-scavenging activity of penicillin G, ampicillin, oxacillin, and dicloxacillin.
- Melanoma and obesity: Should antioxidant vitamins be addressed?
- Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles
- What Are the Links of Prostate Cancer with Physical Activity and Nutrition? : A Systematic Review Article
- M1 and M2 macrophages’ clinicopathological significance in cutaneous melanoma
- ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment
- Targeting of angiopoietin 2-small interfering RNA plasmid/chitosan magnetic nanoparticles in a mouse model of malignant melanoma in vivo
- UV radiation promotes melanoma dissemination mediated by the sequential reaction axis of cathepsins–TGF-β1–FAP-α
- MORINGA OLEIFERA LAM. LEAVES EXTRACT REDUCES HUMAN T-CELL HYPORESPONSIVENESS AND DNA DAMAGE INDUCED BY OXIDATIVE STRESS
- Circulating Protein Carbonyls, Antioxidant Enzymes and Related Trace Minerals among Preterms with Respiratory Distress Syndrome.
- Association Between Oxidative Stress and Melanoma Progression
- Selective Induction of Oxidative Stress in Cancer Cells via Novel Therapeutic Approaches
- Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.
- Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia
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