Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
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Summary
It is proposed that the products of these genes are integral in the assembly of a heterochromatin-like structure, with distinct domains, enclosing the entire centromeric region that reduces or excludes access to transcription factors.
- Type
- article
- Published
- 1995-01-15
- Cited by
- 488
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978197643
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40630092
Keywords
Centromere, Biology, Heterochromatin, Derepression, Genetics
References
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- Mechanisms of heritable gene repression during development of Drosophila.
- Centromeres of the fission yeast Schizosaccharomyces pombe are highly variable genetic loci
- Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere.
- Chromosome walking shows a highly homologous repetitive sequence present in all the centromere regions of fission yeast
- Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I
- Manipulation of large minichromosomes in Schizosaccharomyces pombe with liposome-enhanced transformation.
- Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast.
- Silencers, silencing, and heritable transcriptional states.
- The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.
- The clr1 locus regulates the expression of the cryptic mating-type loci of fission yeast.
- Replicating plasmids in Schizosaccharomyces pombe: improvement of symmetric segregation by a new genetic element
- Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe.
- Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci.
- Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.
- Mammalian chromosome structure.
- Yeast origin recognition complex is involved in DNA replication and transcriptional silencing
- Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.
- A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.
- CENP-B: a major human centromere protein located beneath the kinetochore
Cited by
- Localization and properties of a silencing element near the mat3-M mating-type cassette of Schizosaccharomyces pombe.
- Defects in Components of the Proteasome Enhance Transcriptional Silencing at Fission Yeast Centromeres and Impair Chromosome Segregation
- Novel functional requirements for non‐homologous DNA end joining in Schizosaccharomyces pombe
- Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation
- Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing
- RNA Interference (RNAi)-Dependent and RNAi-Independent Association of the Chp1 Chromodomain Protein with Distinct Heterochromatic Loci in Fission Yeast
- RNA meets chromatin.
- The relationship between chromatin structure and transcriptional activity in mammalian genomes.
- How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly.
- Pericentromeric sister chromatid cohesion promotes kinetochore biorientation.
- RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.
- Histone and DNA modifications in mental retardation.
- H3K9/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development.
- Chromatin proteins are determinants of centromere function.
- Elucidation of the Multi-Faceted Roles of the SIN (Septation Initiation Network); Understanding How the SIN Promotes Cytokinesis and Inhibits Interphase Growth in the Fission Yeast Schizosaccharomyces pombe: A Dissertation
- Mechanisms and dynamics of heterochromatin formation during mammalian development: closed paths and open questions.
- Centromere-competent DNA: structure and evolution.
- The epigenetic basis for centromere identity.
- Heterochromatin, position effects, and the genetic dissection of chromatin.
- Drosophila Telomeric Transgenes Provide Insights on Mechanisms of Gene Silencing
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