A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

J. L. Haines, Monica Ter‐Minassian, A. Bazyk, James F. Gusella, Dong Joon Kim · Nature Genetics · 1996

Summary

A two-stage, multi-analytical genomic screen to identify genomic regions potentially harbouring MS susceptibility genes suggested that a multifactorial aetiology, including both environmental and multiple genetic factors of moderate effect, is more likely than a simple mendelian disease gene(s).

Type: article
Published: 1996-08-01
Cited by: 687
References: 26
DOI: https://doi.org/10.1038/ng0896-469
PubMed: https://pubmed.ncbi.nlm.nih.gov/8696344/
OpenAlex: https://openalex.org/W2089593597
Semantic Scholar: https://api.semanticscholar.org/CorpusID:7587879

Keywords

Biology, Multiple sclerosis, Genetics, Major histocompatibility complex, Candidate gene

References

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Large scale screening of the mitochondrial DNA reveals no pathogenic mutations but a haplotype associated with multiple sclerosis in CaucasiansTeresia A. Carreon, Linda Herrera, Miguel Vasquez — 1999
Chromosome 19 locus apolipoprotein C-II association with multiple sclerosisHamed Zouali, Laurence Faure-Delanef, G Lucotte — 1999
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptorHanna Ericsson — 1999
Evidence for the genetic role of human leukocyte antigens in low frequency DRBI*1501 multiple sclerosis patients in IsraelWarren E. Straszheim, J.G. Yousling, K.A. Younkin — 1999
Linkage disequilibrium analysis of chromosome 12q14–15 in multiple sclerosis: delineation of a 118-kb interval around interferon-γ (IFNG) that is involved in male versus female differential susceptibilityMuki Haklay — 2002
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A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

Summary

Keywords

References

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