Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy
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Summary
Evidence is presented that BNIP3 undergoes several phosphorylation events at its C-terminus, adjacent to the transmembrane domain, providing evidence that the two functional roles of BnIP3 can be regulated independently.
- Type
- article
- Published
- 2015-06-23
- Cited by
- 41
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W1495072173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10388229
Keywords
Cell biology, Autophagy, Phosphorylation, Programmed cell death, Mitochondrion
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- Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase.
- Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue.
- Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
Cited by
- Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin.
- The role of morphogens in B cell development
- A cytological link between radioresistance and autophagy
- Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation
- Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise
- Hypoxia and Selective Autophagy in Cancer Development and Therapy
- Targeted OMA1 therapies for cancer
- STC-1 ameliorates renal injury in diabetic nephropathy by inhibiting the expression of BNIP3 through the AMPK/SIRT3 pathway
- Interplay between Mitophagy and Inflammasomes in Neurological Disorders.
- Ginsenoside Rb3 provides protective effects against cisplatin‐induced nephrotoxicity via regulation of AMPK‐/mTOR‐mediated autophagy and inhibition of apoptosis in vitro and in vivo
- Mitophagy in Cancer: A Tale of Adaptation
- Platinum‐based combination chemotherapy triggers cancer cell death through induction of BNIP3 and ROS, but not autophagy
- Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors
- A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in mice
- Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses
- MICROVASCULAR ENDOTHELIAL CELL ADAPTATION TO HYPOXIA IS ORGAN-SPECIFIC AND CONDITIONED BY ENVIRONMENTAL OXYGEN
- Autophagy markers as mediators of lung injury-implication for therapeutic intervention
- LncRNA SNHG14 promotes OGD/R-induced neuron injury by inducing excessive mitophagy via miR-182-5p/BINP3 axis in HT22 mouse hippocampal neuronal cells
- BNIP3 in Lung Cancer: To Kill or Rescue?
- Mitophagy and the Brain
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