Hypoxia and Selective Autophagy in Cancer Development and Therapy
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Summary
A deeper understanding of the molecular crosstalk between hypoxia response mechanisms and autophagy could provide important insights with relevance to cancer andHypoxia-related pathologies.
- Type
- review
- Published
- 2018-09-10
- Cited by
- 160
- References
- 215
- Access
- Open access
- OpenAlex
- https://openalex.org/W2890767393
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52178117
Keywords
Autophagy, Hypoxia (environmental), Cellular adaptation, Mitophagy, Biology
References
- Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
- FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy
- Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis
- mTOR Activity Under Hypoxia
- CK2: A key player in cancer biology
- NEURONAL HYPOXIA DISRUPTS MITOCHONDRIAL FUSION
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- 2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation - Implications for targeting the Warburg effect in cancer cells.
- Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy
- EPAS1/HIF-2α is a driver of mammalian pexophagy
- Signaling pathways and mechanisms of hypoxia‐induced autophagy in the animal cells
- Autophagy at the crossroads of catabolism and anabolism
- Evaluating tumor metastatic potential by imaging intratumoral acidosis via pH‐activatable near‐infrared fluorescent probe
- Role of BNIP3 in proliferation and hypoxia‐induced autophagy: implications for personalized cancer therapies
- ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS
- Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity
- Calnexin is a novel sero-diagnostic marker for lung cancer.
- Calnexin controls the STAT3-mediated transcriptional response to EGF.
- Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia*
- Downregulation of microRNA-498 in colorectal cancers and its cellular effects.
Cited by
- The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades.
- The Roles of Autophagy in Cancer
- Selective Autophagy Regulates Cell Cycle in Cancer Therapy
- The emerging interrelation between ROCO and related kinases, intracellular Ca2+ signaling, and autophagy.
- Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment
- Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
- Inflammation and Metabolism in Cancer Cell—Mitochondria Key Player
- FUNDC1-mediated mitophagy in bovine papillomavirus-infected urothelial cells.
- A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
- Outstanding Questions in Mitophagy: What we Do and Do Not Know.
- Mitophagy mediated by BNIP3 and BNIP3L/NIX in urothelial cells of the urinary bladder of cattle harbouring bovine papillomavirus infection.
- Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge
- Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function
- A predicted risk score based on the expression of 16 autophagy-related genes for multiple myeloma survival
- Autophagy as a novel therapeutic target in vascular calcification.
- Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.
- Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl)benzothiazole derivatives as potential antioxidant, antibacterial and antitumor agents.
- The Multifaceted Effects of Autophagy on the Tumor Microenvironment.
- Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
- Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele
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