Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.
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Summary
It is demonstrated that mTOR is a component of a cytokine‐triggered protein kinase cascade leading to the phosphorylation of the eukaryotic initiation factor‐4E (eIF‐4 E) binding protein, PHAS‐1, in activated T lymphocytes.
- Type
- article
- Published
- 1996-10-01
- Cited by
- 753
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1797700808
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21846434
Keywords
Wortmannin, LY294002, Medicine, Kinase, Biology
References
- Control of PHAS-I by Insulin in 3T3-L1 Adipocytes
- Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells.
- The TOR signalling pathway and growth control in yeast.
- PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity.
- Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.
- Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.
- A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
- Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.
- Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
- Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.
- Repression of cap‐dependent translation by 4E‐binding protein 1: competition with p220 for binding to eukaryotic initiation factor‐4E.
- Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
- Bioassay of interleukins
- When is a lipid kinase not a lipid kinase? When it is a protein kinase.
- DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
- TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin.
- Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
- lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin
- ATM-related genes: what do they tell us about functions of the human gene?
- Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
Cited by
- Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
- Abnormalities of protein kinases in neurodegenerative diseases.
- Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases.
- Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes
- Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor*
- Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/− compound mutant mice
- p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells*
- Novel aspects of renal tubulointerstitial fibrosis
- Regulation of eukaryotic initiation factor eIF2B.
- Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
- Investigation of protein expression dynamics in human tumor cells following pharmacological treatment
- The involvement of phosphoinositide 3-kinase in murine lung branching morphogenesis and insights into protein mediated drug delivery
- Inflammatory signaling in skeletal muscle cell growth
- New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).
- The roles of the preproghrelin-derived peptides - ghrelin, desacyl ghrelin and obestatin - in prostate cancer
- Phosphoinositides in chemotaxis.
- Insulin signaling and the control of PHAS-I phosphorylation.
- RNA virus modulation of IFN, PI3K and apoptosis
- Control of translation by the target of rapamycin proteins.
- Regulation of protein synthesis by insulin through IRS-1.
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