P53: LA HISTORIA SIN FINAL DE UN POLIFACÉTICO GUARDIÁN
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Summary
The p53 gene is not only recognized for being a tumor repressor, but also for playing a leading role in other cellular processes such as maintaining the integrity of the genome, apoptosis, senescence and development, among others.
- Type
- article
- Published
- 2009-12-01
- Cited by
- 0
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W1489753456
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82150224
Keywords
Scope (computer science), Gene, Repressor, Biology, Genome
References
- Function of the p53 gene: choice between life and death.
- Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
- Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
- Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
- p53 modulation of anchorage independent growth and experimental metastasis.
- Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.
- Sequence‐specific DNA binding by p53: identification of target sites and lack of binding to p53 ‐ MDM2 complexes.
- Analysis of recombinant DNA clones specific for the murine p53 cellular tumor antigen.
- Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40‐transformed cells.
- Taxol induction of p21WAF1 and p53 requires c-raf-1.
- 25 years of p53 research
- Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
- p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
- Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
- Why do we age?
- Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies
- A transcriptionally active DNA-binding site for human p53 protein complexes
- Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
- Expression of the mouse p53 cellular tumor antigen in monkey cells
- Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
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