Endothelial autophagy and Endothelial-to-Mesenchymal Transition (EndoMT) in eEPC treatment of ischemic AKI
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Summary
In ischemic AKI, intrarenal endothelial autophagy may be stabilized by systemic administration of pharmacologically preconditioned eEPCs, which can reduce postischemic EndoMT and fibrosis in the mid-term.
- Type
- article
- Published
- 2015-08-20
- Cited by
- 29
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1201291120
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15059672
Keywords
Autophagy, Medicine, Mesenchymal stem cell, Pharmacology, Fibrosis
References
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- Potential advantages of acute kidney injury management by mesenchymal stem cells.
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- Inflammatory cells in ischemic acute renal failure.
- Chronic NOS inhibition actuates endothelial-mesenchymal transformation.
- Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.
- Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
- Uric acid heralds ischemic tissue injury to mobilize endothelial progenitor cells.
- The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury.
- Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells.
- Autophagy: The missing link between non-enzymatically glycated proteins inducing apoptosis and premature senescence of endothelial cells?
- Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway.
- Fibrate treatment of eEOCs in murine AKI
- Angiopoietin-1 treated early endothelial outgrowth cells (eEOCs) are activated in vitro and reduce renal damage in murine acute ischemic kidney injury (iAKI)
- Ischemic acute renal failure: an inflammatory disease?
- Dysfunctional endothelial progenitor cells in chronic kidney disease.
- Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition.
- Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice
- Stress-induced premature senescence of endothelial cells: a perilous state between recovery and point of no return
Cited by
- Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3.
- Interactions between Autophagy and Inhibitory Cytokines
- Acute Kidney Injury in Diabetes Mellitus
- Endothelial Colony Forming Cells (ECFCs) in murine AKI – implications for future cell-based therapies
- Endothelial colony forming cells and proangiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury
- Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
- Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells
- Dexmedetomidine attenuates renal fibrosis via &agr;2‐adrenergic receptor‐dependent inhibition of cellular senescence after renal ischemia/reperfusion
- Acute and chronic effects of metabolic acidosis on renal function and structure
- Endothelial Progenitor Cells and Kidney Diseases
- Effects of autophagy on cell migration and apoptosis of endothelial progenitor cells in hypoxic environment
- Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via nAChRs/ROS/NF-κB signaling pathway.
- Histone Deacetylase Inhibitors Reduce Cysts by Activating Autophagy in Polycystic Kidney Disease
- Spio nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by Sio2.
- Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
- Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic Diseases
- Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury
- Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy
- A promising field: regulating imbalance of EndMT in cardiovascular diseases
- Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties
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