Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3.
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Summary
Autophagy counteracts the EndoMT process triggered by TGF-β2 by decreasing the phosphorylation level of Smad3, demonstrating a role of autophagy in regulating Snail production both by transcriptional and post-transcriptional mechanism.
- Type
- dissertation
- Published
- 2017-06-03
- Cited by
- 24
- References
- 33
- OpenAlex
- https://openalex.org/W28450107
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42722930
Keywords
Humanities, Geography, Art
References
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- Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation
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- Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
- Fibrosis--a common pathway to organ injury and failure.
- The Essential Autophagy Gene ATG7 Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition*
- The role of endothelial–mesenchymal transition in development and pathological process
- Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections.
- Role of Smads in TGFβ signaling
- Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
- Targeting Cardiac Fibroblasts to Treat Fibrosis of the Heart: Focus on HDACs
- Mechanisms of age-related macular degeneration
- Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition
- Regulation of autophagy by transforming growth factor-β (TGF-β) signaling
- Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis
- Origin and Function of Myofibroblasts in Kidney Fibrosis
- Retinal pigment epithelium tears following ranibizumab for exudative age-related macular degeneration.
- Age-related macular degeneration and blindness due to neovascular maculopathy.
Cited by
- Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
- The therapeutic potential of targeting the endothelial-to-mesenchymal transition
- Molybdenum Disulfide Quantum Dots Attenuates Endothelial-to-Mesenchymal Transition by Activating TFEB-Mediated Lysosomal Biogenesis.
- Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?
- Spio nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by Sio2.
- Caveolin-1 deficiency increases autophagy in the endothelium and attenuates vascular inflammation and atherosclerosis
- Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy.
- Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic Diseases
- Markers of Endothelial Cells in Normal and Pathological Conditions
- Autophagy modulates mesenchymal-to-endothelial transition via p53
- Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties
- Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects
- The Role of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease
- Endothelial mesenchymal transformation and relationship with vascular abnormalities
- Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress.
- A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial–mesenchymal transition in Schlemm’s canal endothelial cells
- Mechanical stress induced EndoMT in endothelial cells through PPARγ downregulation.
- Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis
- Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
- Endothelium, Aging, and Vascular Diseases
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