Chapter 37: The phosphoinositide signalling system. I. Historical background. II. Effects of lithium on the accumulation of second messenger inositol 1,4,5-trisphosphate in brain cortex slices
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Summary
Inositol lipids in cell membranes are cleaved to inositol phosphates and diacylglycerol, which activates protein kinase C, which phosphorylates a different set of proteins, leading to a variety of biological responses.
- Type
- review
- Published
- 1993-01-01
- Cited by
- 13
- References
- 28
- OpenAlex
- https://openalex.org/W1172788676
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32147000
Keywords
Second messenger system, Phosphatidylinositol, Diacylglycerol kinase, Inositol, Inositol trisphosphate receptor
References
- The measurement of 32P labelling of individual kephalins and lecithin in a small sample of tissue.
- Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices.
- Chromatography of phosphatides on silicic acid impregnated paper.
- The synthesis of phosphatidic acid from diglyceride and adenosine triphosphate in extracts of brain microsomes.
- Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine.
- Kinetic analysis of the formation of inositol 1:2-cyclic phosphate in carbachol-stimulated pancreatic minilobules. Half is formed by direct phosphodiesteratic cleavage of phosphatidylinositol.
- Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices.
- Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.
- The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
- Reduced brain inositol in lithium-treated rats.
- Inositol phosphates and cell signalling
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
- Lithium Enhances Accumulation of [3H]Inositol Radioactivity and Mass of Second Messenger Inositol 1,4,5‐Trisphosphate in Monkey Cerebral Cortex Slices
- Protein kinase C in transmembrane signalling
- Inositol lipids in cellular signalling mechanisms.
- Inositol phosphate biochemistry.
- Inositol phospholipids and cell surface receptor function.
- Acetylcholine action: biochemical aspects.
- II. Biochemical mechanisms in the phosphatidylinositol effect
- Neural and developmental actions of lithium: a unifying hypothesis.
Cited by
- Cholinergic Neurotransmission and Synaptic Plasticity Concerning Memory Processing
- Energy Consumption by Phospholipid Metabolism in Mammalian Brain
- Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study.
- Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices.
- Targeted liquid chromatography quadrupole ion trap mass spectrometry analysis of tachykinin related peptides reveals significant expression differences in a rat model of neuropathic pain.
- Interactions between calcium release pathways: multiple messengers and multiple stores.
- Pharmacogenetics in model systems: Defining a common mechanism of action for mood stabilisers
- Prodrugs of phosphates and phosphonates: Novel lipophilic α-acyloxyalkyl ester derivatives of phosphate- or phosphonate containing drugs masking the negative charges of these groups
- Additive effects of glyburide and antidepressants in the forced swimming test: evidence for the involvement of potassium channel blockade.
- BIPOLAR DISORDER AND MECHANISMS OF ACTION OF MOOD STABILIZERS
- Gene Regulation by Drugs Used to Treat Mood Disorders
- Characterization of Substance P processing in mouse spinal cord S9 fractions using high-resolution Quadrupole-Orbitrap mass spectrometry.
- Biochemical and Physiological Processes in Brain Function and Drug Actions
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