A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules
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Summary
During the characterization of epitopes of the malaria parasite Plasmodium falciparum, a sequence of the circumsporozoite protein was analysed, and it was found that synthetic peptides corresponding to this sequence are recognized by T cells in association with many different MHC class II molecules, both in mouse and in man.
- Type
- article
- Published
- 1988-12-22
- Cited by
- 397
- References
- 25
- OpenAlex
- https://openalex.org/W2026893977
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4333483
Keywords
Circumsporozoite protein, Major histocompatibility complex, Epitope, Biology, Plasmodium falciparum
References
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- Assessment in mice of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, P. falciparum.
- Human T cells recognize polymorphic and non‐polymorphic regions of the Plasmodium falciparum circumsporozoite protein.
- Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum.
- Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development.
- Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice.
- The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides
- Detection of a novel human class II HLA antigen
- Circumsporozoite gene of a Plasmodium falciparum strain from Thailand.
- Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine
- The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.
- Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein
- Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.
- T-cell antigenic sites tend to be amphipathic structures.
- Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes
- DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope.
- A small polypeptide different from β2-microglobin associated with a human cell surface antigen
- Murine Monoclonal Antibodies against HLA Structures
- Structure of the human class I histocompatibility antigen, HLA-A2
- Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients
Cited by
- Accuracy of a structural homology model for a class II histocompatibility protein, HLA-DR1: comparison to the crystal structure.
- Human T-cell clones to the 70-kilodalton heat shock protein of Mycobacterium leprae define mycobacterium-specific epitopes rather than shared epitopes
- Breaking the Non‐Responsiveness of C57BL/6 Mice to the Malarial Antigen EB200 – The Role of Carrier and Adjuvant Molecules
- Cellular immunology of tetanus toxoid.
- Identification of MHC class II binding peptides: microarray and soluble MHC class II molecules.
- Peptide-MHC complexes assembled following multiple pathways: an opportunity for the design of vaccines and therapeutic molecules.
- Malaria vaccine development using synthetic peptides as a technical platform.
- Progress toward a malaria vaccine.
- Future potential of malaria vaccines.
- Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules
- Recent developments in malaria vaccinology.
- Determination of the Agretopic Residues of a Peptide Co‐Restricted to Different Class II Isotypes, I‐Au and I‐Eu, and Its Application for Preparation of a Synthetic Peptide Vaccine against Influenza Virus A/Aichi/2/68
- Selection of T cell epitopes and vaccine engineering.
- Does pregnancy immunize against breast cancer?
- The Dermatophagoides pteronyssinus Group 2 Allergen Contains a Universally Immunogenic T Cell Epitope
- Unique T Cell Effector Functions Elicited by Plasmodium falciparum Epitopes in Malaria-Exposed Africans Tested by Three T Cell Assays1
- Identification of two T-cell epitopes on the candidate Epstein-Barr virus vaccine glycoprotein gp340 recognized by CD4+ T-cell clones
- The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases.
- Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice.
- Spontaneous CD4+ T Cell Responses against TRAG-3 in Patients with Melanoma and Breast Cancers1
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