Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
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Summary
The five glioma molecular groups had different ages at onset, overall survival, and associations with germline variants, which implies that they are characterized by distinct mechanisms of pathogenesis.
- Type
- article
- Published
- 2015-06-10
- Cited by
- 1,811
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W571060166
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205096977
Keywords
Glioma, Germline mutation, Medicine, Germline, Somatic cell
References
- Surveys 2011 & Anatomic Pathology Education Programs
- International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading
- Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
- PVT1 dependence in cancer with MYC copy-number increase
- A low frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and IDH1 or IDH2 mutated astrocytomas
- Germline mutations in shelterin complex genes are associated with familial glioma.
- Genome-wide association study identifies five susceptibility loci for glioma
- Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
- Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target
- Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma
- A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
- Deciphering the 8q24.21 association for glioma.
- Telomerase promoter mutations in cancer: an emerging molecular biomarker?
- Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.
- A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma.
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- The Somatic Genomic Landscape of Glioblastoma
- Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes
- Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
- Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
Cited by
- Central Nervous System: Progress of Today and a Preview of Tomorrow.
- Laser Ablation vs Open Resection for Deep-Seated Tumors: The Case for Open Resection.
- The Safety of Available Immunotherapy for the Treatment of Glioblastoma
- The Role of Histone Modifications and Telomere Alterations in the Pathogenesis of Diffuse Gliomas in Adults and Children
- Therapeutic Options for Recurrent High-Grade Gliomas: A Perspective Statement.
- Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history
- Investigation of the usefulness of fluorescein sodium fluorescence in stereotactic brain biopsy
- Efficacy and prognosis of surgery combined with 125I seed implantation in treatment of recurrent glioma
- Machine learning classifies cancer
- Reclassification of 400 consecutive glioma cases based on the revised 2016WHO classification
- The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas
- The Applicability of Haarlem Integrated Diagnostic System in Diffuse Glial Tumors and Molecular Methods Affecting Prognosis
- Deep learning can see the unseeable: predicting molecular markers from MRI of brain gliomas.
- Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implications
- Recent Molecular Advances in Our Understanding of Glioma
- Progress in the application of molecular biomarkers in gliomas.
- Association of Telomerase Reverse Transcriptase Promoter Mutations with the Prognosis of Glioma Patients: a Meta-Analysis
- Circulating biomarkers for gliomas
- Genetic Classification of Gliomas: Refining Histopathology.
- BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology
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