BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology
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Summary
To address the hypothesis that genomic alterations could segregate spinal cord astrocytoma histologic grades, sequencing of cancer-related genes in a cohort of 17 tumors was performed and revealed a BRAF amplification resulted from a chromosome 7 arm level gain in three of these specimens.
- Type
- letter
- Published
- 2015-10-20
- Cited by
- 53
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W1779832721
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10145678
Keywords
Medicine, Spinal cord, Astrocytoma, Pathology, Pilocytic astrocytoma
References
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- Phase 1 study of dabrafenib in pediatric patients (pts) with relapsed or refractory BRAF V600E high- and low-grade gliomas (HGG, LGG), Langerhans cell histiocytosis (LCH), and other solid tumors (OST).
Cited by
- Genetic mutations in high grade gliomas of the adult spinal cord
- Targeting Epigenetic Pathways in the Treatment of Pediatric Diffuse (High Grade) Gliomas
- Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
- The significance of histone H3 K27M mutation in brain tumors
- Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.
- Recent advances in intradural spinal tumors
- H3 K27M-mutant diffuse midline gliomas in different anatomical locations.
- Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
- Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.
- Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics
- A Rare Case of Diffuse Midline Glioma, H3 K27M Mutant, of the Spinal Cord Mimicking Meningitis
- H3k27m- Positive Primary Spinal Gliobastoma Presenting With Haemorrhage- A Rare Clinical Entity.
- Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations
- Molecular foundations of primary spinal tumors-implications for surgical management.
- Clinical relevance of BRAF status in glial and glioneuronal tumors: A systematic review.
- Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials
- Spinal Cord Tumors
- Genomic Landscape of Intramedullary Spinal Cord Gliomas
- Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care.
- Spinal cord anaplastic astrocytoma with BRAF V600E mutation: A case report and review of literature
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