Clinical applications of N-acetylcysteine.
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Summary
N-acetylcysteine also appears to have some clinical usefulness as a chelating agent in the treatment of acute heavy metal poisoning, both as an agent capable of protecting the liver and kidney from damage and as an intervention to enhance elimination of the metals.
- Type
- article
- Published
- 1998-04-01
- Cited by
- 326
- References
- 85
- OpenAlex
- https://openalex.org/W146410082
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20577227
Keywords
Acetylcysteine, Glutathione, Oxidative stress, Detoxification (alternative medicine), Chemistry
References
- The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid.
- DNA damage induced by chloramphenicol and nitroso-chloramphenicol: protection by N-acetylcysteine.
- N-acetylcysteine treatment and the risk of toxic reactions to trimethoprim-sulphamethoxazole in primary Pneumocystis carinii prophylaxis in HIV-infected patients.
- Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability.
- N-Acetylcysteine therapy of acute heavy metal poisoning in mice.
- Hypersensitivity-like reactions to N-acetylcysteine.
- Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers.
- Acetylcysteine: a drug that is much more than a mucokinetic.
- 2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC.
- Pharmacokinetics of Oral Acetylcysteine: Absorption, Binding and Metabolism in Patients with Respiratory Disorders
- Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression.
- Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables.
- Protection against pulmonary O2 toxicity by N-acetylcysteine.
- Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokers.
- The role of glutathione status in the protection against ischaemic and reperfusion damage: effects of N-acetyl cysteine.
- Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine.
- The effects of homocysteine and copper ions on the concentration and redox status of thiols in cell line cultures.
- N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels.
- Concomitant use of activated charcoal and N-acetylcysteine.
- A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.
Cited by
- Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens.
- Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation
- N-acetyl-l-cysteine protects dental tissue stem cells against oxidative stress in vitro
- Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.
- Effects of N-acetylcysteine on oxidative stress in rats with non-alcoholic steatohepatitis.
- N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention
- Preventive potential of N-acetylcysteine in oxidative stress-related complications of prematurity
- Efficacy of N-Acetylcysteine and Hydrated Sodium Calcium Aluminosilicate to Reduce the Effects of Aflatoxin B1 Intoxication in Broiler Chickens
- Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes1
- Placental function in maternal disease; ex vivo assessment of foetoplacental vascular function and transport in diabetes and preeclampsia.
- Experimental Antioxidant Therapy in Ataxia Telangiectasia
- Intervenciones antioxidantes para el tratamiento del estrés oxidativo y muerte celular en hepatocitos humanos en cultivo
- Treatment of refractory thrombotic thrombocytopenic purpura with N‐acetylcysteine: a case report
- REACTIVE OXYGEN SPECIES: IMPACT ON SKELETAL MUSCLE
- JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells
- Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration
- Fibroblasts Behavior after N-Acetylcysteine and Amino Acids Exposure: Extracellular Matrix Gene Expression
- IMPACT DE LA FAIBLESSE MUSCULAIRE SUR LA TOLERANCE A L'EFFORT ET LA QUALITE DE VIE DES PATIENTS ATTEINTS DE BPCO : BENEFICE DU REENTRAINEMENT A L'EFFORT
- Recovery by N-acetylcysteine from subchronic exposure to Imidacloprid-induced hypothalamic–pituitary–adrenal (HPA) axis tissues injury in male rats
- Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments
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