Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression.
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Summary
It is concluded that high-dose NAC significantly improved the antioxidant screen of the lungs by elevating GSH levels and the decrease of Met(O) levels indicated an antioxidant effect at the alveolar surface.
- Type
- article
- Published
- 1997-12-01
- Cited by
- 299
- References
- 32
- OpenAlex
- https://openalex.org/W1853423207
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13141567
Keywords
Glutathione, Acetylcysteine, Bronchoalveolar lavage, Medicine, Oxidative stress
References
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- Die Lungenfunktion : Physiologie und Pathophysiologie, Methodik
- Glutathione disulfide (GSSG) efflux from cells and tissues.
- Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.
- Analysis of methionine sulfoxide in proteins.
- Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.
- Increased levels of oxidized methionine residues in bronchoalveolar lavage fluid proteins from patients with idiopathic pulmonary fibrosis.
- Bronchoalveolar lavage for evaluation and management of scleroderma disease of the lung.
- Oxygen radical production by alveolar inflammatory cells in idiopathic pulmonary fibrosis.
- Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis.
- Inhibition of collagen gelation by action of the superoxide radical.
- Oxidants/antioxidants in idiopathic pulmonary fibrosis.
- Oxidative autoactivation of latent collagenase by human neutrophils.
- Oxidant injury of lung parenchymal cells.
- Tissue destruction by neutrophils.
- Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis.
- Interstitial lung disease: current concepts of pathogenesis, staging and therapy.
- Pathogenetic significance of reactive oxygen species in diffuse fibrosing alveolitis.
- Effect of oxygen-derived free radicals on hyaluronic acid.
- Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution.
Cited by
- Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts.
- Idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis
- Treatment of idiopathic pulmonary fibrosis: Is there anything new?
- The evolving pharmacotherapy of pulmonary fibrosis
- S2K-Leitlinie zur Diagnostik und Therapie der idiopathischen Lungenfibrose
- Therapie der idiopathischen Lungenfibrose
- Grundlagen der antiinflammatorischen Wirkung von N-Acetylcystein und dessen therapeutische Einsatzmöglichkeiten
- The role of apoptosis in pulmonary fibrosis.
- Clinical applications of N-acetylcysteine.
- Extracellular Superoxide Dismutase and Matrix Metalloproteinases in Pulmonary Fibrosis
- Idiopathic pulmonary fibrosis : from epidemiology to gene mapping
- Preventive potential of N-acetylcysteine in oxidative stress-related complications of prematurity
- Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats.
- Idiopathic pulmonary fibrosis.
- Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.
- Non-steroid agents for idiopathic pulmonary fibrosis.
- Immunomodulatory agents for idiopathic pulmonary fibrosis.
- New developments in the therapy of pulmonary fibrosis.
- Modulatory Effects of Curcumin and Green Tea Extract against Experimentally Induced Pulmonary Fibrosis: A Comparison with N‐Acetyl Cysteine
- IMPACT DE LA FAIBLESSE MUSCULAIRE SUR LA TOLERANCE A L'EFFORT ET LA QUALITE DE VIE DES PATIENTS ATTEINTS DE BPCO : BENEFICE DU REENTRAINEMENT A L'EFFORT
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