Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability.
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Summary
It is concluded that deacetylation in the intestinal mucosa and possibly in the intestine lumen is the major factor determining the low oral bioavailability of N-acetyl-L-cysteine.
- Type
- article
- Published
- 1989-11-15
- Cited by
- 107
- References
- 27
- OpenAlex
- https://openalex.org/W36026161
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26050038
Keywords
Cysteine, Acetylation, Cytosol, Biochemistry, Small intestine
References
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- Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.
- The metabolism of 35S-D-penicillamine in man.
- Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems.
Cited by
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- Microglial glutathione and glutamate: regulation mechanisms
- Clinical applications of N-acetylcysteine.
- Preventive potential of N-acetylcysteine in oxidative stress-related complications of prematurity
- Use of N-acetylcysteine in Obsessive-Compulsive and Related Disorders
- [48] N-acetylcysteine
- Bioconversion of prodrugs by conjugate-processing enzymes.
- Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H2O2.
- The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.
- On the dark side of light: Genesis and prevention of two spectral types of retinal light damage
- N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial.
- Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men
- Prodrugs as drug delivery systems. 107. Synthesis and chemical and enzymatic hydrolysis kinetics of various mono- and diester prodrugs of N-acetylcysteine
- Antioxidants Inhibit Stimulation of HIV Transcription
- Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs.
- Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis.
- Synthesis of new N-isobutyryl-L-cysteine/MEA conjugates: evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages.
- Early onset senescence occurs when fibroblasts lack glutamate cysteine ligase modifier subunit
- Oral N-acetyl-L-cysteine is a safe and effective precursor of cysteine.
- N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels.
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