Earlier intervention in the management of hypercholesterolemia: what are we waiting for?
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Summary
The thesis advanced here is that the authors are initiating treatment of hypercholesterolemia (and other risk factors) too late in life, and starting treatment at, for example, age 30 years instead of age 60 years might very well prevent not just 30% of events, as in the 5-year statin trials, but perhaps as many as 60%.
- Type
- article
- Published
- 2010-08-17
- Cited by
- 50
- References
- 19
- Access
- Open access
- OpenAlex
- https://openalex.org/W79453784
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205535887
Keywords
Medicine, Intervention (counseling), Familial hypercholesterolemia, Gerontology, Intensive care medicine
References
- The National Diet-Heart Study Final Report.
- Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study.
- Starting earlier to prevent heart disease.
- Coronary disease among United States soldiers killed in action in Korea; preliminary report.
- The Cholesterol Wars: The Cholesterol Skeptics vs the Preponderance of Evidence
- Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
- High Prevalence of Coronary Atherosclerosis in Asymptomatic Teenagers and Young Adults: Evidence From Intravascular Ultrasound
- Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.
- Statins for primary prevention of coronary artery disease.
- Lifetime risk of coronary heart disease by cholesterol levels at selected ages.
- Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
- Statins for primary prevention of coronary artery disease.
- Evidence mandating earlier and more aggressive treatment of hypercholesterolemia.
- Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study.
- Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
- Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
- Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
- Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults
Cited by
- The case for treating hypercholesterolemia at an earlier age: moving toward consensus.
- Statin therapy in young adults: ready for prime time?
- Statins and musculoskeletal adverse events--reply.
- Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.
- The effect of high-fat meals and exercise on endothelial function and triacylglycerol concentrations in adolescent boys
- Do Statins Cause Diabetes?
- Statins and musculoskeletal conditions, arthropathies, and injuries.
- Statins and musculoskeletal adverse events.
- Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association.
- Incidence of Musculoskeletal and Neoplastic Diseases in Patients on Statin Therapy: Results of a Retrospective Cohort Analysis
- Cardiovascular risk stratification, hemoglobin a1c, and the tempo of translation: comment on "Cardiovascular risk prediction in diabetic men and women using hemoglobin A1c vs diabetes as a high-risk equivalent".
- Cost-Effectiveness of Statin Therapy for Primary Prevention in a Low-Cost Statin Era
- Primary prevention of cardiovascular events in patients with major mental illness: a possible role for statins
- Technical difficulties and evaluating e-health interventions--reply.
- Technical difficulties and evaluating e-health interventions.
- A Randomized Trial of Personal Genomics for Preventive Cardiology: Design and Challenges
- The Evolution or Revolution of Statin Therapy in Primary Prevention: Where Do We Go From Here?
- The Rationale for Initiating Treatment of Hypercholesterolemia in Young Adulthood
- Evidence-based use of statins for primary prevention of cardiovascular disease.
- Coronary Artery Disease Detected by Coronary Computed Tomographic Angiography Is Associated With Intensification of Preventive Medical Therapy and Lower Low-Density Lipoprotein Cholesterol
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