Mildronate, a Novel Fatty Acid Oxidation Inhibitor and Antianginal Agent, Reduces Myocardial Infarct Size Without Affecting Hemodynamics

Keywords

Medicine, Ventricle, Hemodynamics, Ischemia, Myocardial infarction

References

• [Definition of therapeutic effect of mildronate in patients with chronic heart failure].V Chumburidze, T Kikalishvili, T Sulashvili — 2005
• Detrimental actions of endogenous fatty acids and their derivatives. A study of ischaemic mitochondrial injury.H. M. Piper, Abhishek Das — 1987
• Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia.Teruhiko Aoyagi, Seiryo Sugiura, Yoko Eto — 1996
• Mildronate: cardioprotective action through carnitine-lowering effect.Maija Dambrova — 2002
• Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum.Kathryn A. Yamada, Evelyn M. Kanter, Amit Newatia — 2000
• Simvastatin-induced myocardial protection against ischemia–reperfusion injury is mediated by activation of ATP-sensitive K+ channelsShahin Tavackoli, Taras V. Ashitkov, Zhao-Yong Hu — 2004
• Ventricular Remodeling After Myocardial Infarction: Experimental Observations and Clinical ImplicationsMarc A. Pfeffer, Eugene Braunwald — 1990
• The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study.David P. Faxon, Raymond J. Gibbons, Nicolas A.F. Chronos — 2002
• Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart.S. D. DaTorre — 1991
• The Reduction of Infarct Size — An Idea Whose Time (For Testing) Has ComeEugene Braunwald, Peter R. Maroko — 1974
• Cardioprotective profile of MET‐88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat heartsNaomasa Asaka, Yoshinori Muranaka, Tsukasa Kirimoto — 1998
• Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the ratPascal Degrace, Laurent Demizieux, Joseph Gresti — 2004
• Effectors of fatty acid oxidation reduction: promising new anti-ischaemic agents.Alain Grynberg — 2005
• Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarctionKatsunori Yonekura, Yoko Eto, Ikuo Yokoyama — 2000
• Double-Blind, Randomized Trial of an Anti-CD18 Antibody in Conjunction With Recombinant Tissue Plasminogen Activator for Acute Myocardial Infarction: Limitation of Myocardial Infarction Following Thrombolysis in Acute Myocardial Infarction (LIMIT AMI) StudyKenneth W. Baran, Michel Nguyen, George R. McKendall — 2001
• Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury.Y BIRNBAUM, Yun Ye, Salvatore Rosanio — 2005
• 3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.Boris Z. Simkhovich, Zhanna V. Shutenko, Dainuvīte V. Meirēna — 1988
• Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.Kathryn A. Yamada, J McHowat, Gan‐Xin Yan — 1994
• Effect of L-carnitine on mitochondrial acyl CoA esters in the ischemic dog heart.Akira Kobayashi, Shigeki Fujisawa — 1994
• Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction.Yukio Hayashi, Tsukasa Kirimoto, Naomasa Asaka — 2000

Cited by

• Транзиторная ишемия миокарда и методы её коррекции в периоперационном периоде при абдоминальных хирургических вмешательствахВ. П. Михин, Н. А. Волкова, С. А. Сумин — 2014
• Cell Biology of Ischemia/Reperfusion InjuryTheodore J. Kalogeris, Christopher Baines, Maike Krenz — 2012
• The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndromeGerald J. Maarman — 2010
• Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarctionEdgars Liepinsh, Marina Makrecka‐Kuka, Janis Kuka — 2015
• Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart InfarctionEdgars Liepinsh, Reinis Vilšķe̅rsts, Dagnija Loča — 2006
• Protective effects of mildronate in an experimental model of type 2 diabetes in Goto‐Kakizaki ratsEdgars Liepinsh, Reinis Vilšķe̅rsts, Liga Zvejniece — 2009
• Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial functionSonata Trumbeckaitė, Marius Kinčius, Andrius Preidis — 2009
• Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl ratsReinis Vilšķe̅rsts, Janis Kuka, Baiba Švalbe — 2011
• Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat HeartReinis Vilšķe̅rsts, Edgars Liepinsh, Janis Kuka — 2009
• Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.Edgars Liepinsh, Reinis Vilšķe̅rsts, Elina Skapare — 2008
• Possibility for Application of 99mTc-Methoxyisobutylisonitrile in Assessing the Efficiency of Chemotherapy Cardiotoxicity PreventionВ. И. Чернов, Tatiana V. Kravchuk, Roman Zelchan — 2015
• γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.Luc Henry, Ivanhoe K. H. Leung, Timothy D. W. Claridge — 2012
• Efficacy and Safety of Mildronate for Acute Ischemic Stroke: A Randomized, Double-Blind, Active-Controlled Phase II Multicenter TrialYi Zhu, Guangyun Zhang, Jun Zhao — 2013
• Antagonist molecules in the treatment of anginaAshish Gupta, David E. Winchester, Carl J. Pepine — 2013
• Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.Edgars Liepinsh, Elina Skapare, Baiba Švalbe — 2011
• Determination of Mildronate in Human Plasma and Urine by UPLC–Positive Ion Electrospray Tandem Mass SpectrometryLi‐Jing Cai, Jun Zhang, Peng Wen-xing — 2011
• Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug.Vija Kluša, Jolanta Pupure, Sergejs Isajevs — 2006
• Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR–/– MiceReinis Vilšķe̅rsts, Edgars Liepinsh, Łukasz Mateuszuk — 2009
• Nonlinear pharmacokinetic properties of mildronate capsules: a randomized, open‐label, single‐ and multiple‐dose study in healthy volunteersJun Zhang, Li‐Jing Cai, Jian Yang — 2013
• Effects of long-term mildronate treatment on cardiac and liver functions in rats.Edgars Liepinsh, Janis Kuka, Baiba Švalbe — 2009

Related papers

• The Value of N-terminal proBNP in Acute Myocardial InfarctionLanfeng Wang — 2007
• [Myocardial performance index: prediction and monitoring of remodeling and functioning of the left ventricle after first myocardial infarction].Vera Celic, Milica Dekleva, Anka Majstorovic — 2010
• [Electrocardiographic data suggesting anteroseptal myocardial infarction, in presence of infarction of the left ventricle].Abundes Velasco A, Navarro Robles J, Autrey Caballero A — 1997
• Correlation of electrocardiographic and pathologic findings in healed myocardial infarction.William J. Sullivan, Zeev Vlodaver, Naip Tuna — 1978
• Electrophysiologic effects of acute myocardial infarction in man.Isaac Wiener, Bruce P. Mindich, Joel Kupersmith — 1978
• [Effects of restored blood flow on the contractile function of the right ventricle in patients with acute myocardial infarct: data of two-dimensional computerized echocardiography].Romananovskiĭ Im, Chikvashvili Di, Samko An — 1991
• Hemodynamic alterations in idiopathic myocardiopathy including cineangiography from the left heart chambers.Raymond J. Pietras, William R. Meadows, Milton L. Fort — 1965
• Comparison of hemodynamic changes with general or local anesthesia during dental treatment in pediatric patients: A prospective clinical study.Silvia Pérez‐García, Johanna Acosta‐Ibarra, Juan Antonio Ruiz‐Roca — 2023
• A comparative study between nitroglycerine spray and lignocaine spray to attenuate hemodynamic changes during laryngoscopy and intubationGirish Verma, Aseem Sharma — 2020
• A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia SusceptibilityOmid Sayadi, Dheeraj Puppala, Nosheen Ishaque — 2014