Detrimental actions of endogenous fatty acids and their derivatives. A study of ischaemic mitochondrial injury.
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Summary
The results indicate that fatty acids, when administered to ischaemic myocardium, interfere with mitochondrial membranes at several sites, probably by their CoA esters.
- Type
- article
- Published
- 1987-01-01
- Cited by
- 16
- References
- 22
- OpenAlex
- https://openalex.org/W305439414
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1230295
Keywords
Oxidative phosphorylation, Mitochondrion, Biochemistry, Acyl-CoA, Chemistry
References
- The control of Ca2+ release from heart mitochondria.
- Physical properties of fatty acyl-CoA. Critical micelle concentrations and micellar size and shape.
- Reversible inhibition of mitochondrial adenosine diphosphate phosphorylation by long chain acyl coenzyme A esters.
- Coenzyme A and carnitine distribution in normal and ischemic hearts.
- Mitochondrial acyl-CoA, adenine nucleotide translocase activity and oxidative phosphorylation in myocardial ischaemia.
- The inhibition of adenine nucleotide translocase activity by oleoyl CoA and its reversal in rat liver mitochondria.
- The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles.
- Influence of free fatty acids on myocardial oxygen consumption and ischemic injury.
- Fatty acid-membrane interactions in isolated cardiac mitochondria and erythrocytes.
- Specific inhibition of mitochondrial Ca++ transport by ruthenium red.
- Composition, structure, and function of complex III of the respiratory chain.
- Effect of free fatty acid structure on binding to rat liver mitochondria.
- Development of ischemia-induced damage in defined mitochondrial subpopulations.
- Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium.
- Amphipathic metabolites and membrane dysfunction in ischemic myocardium.
- Mitochondrial complexes I, II, III, IV, and V in myocardial ischemia and autolysis.
- Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium.
- Oxidative metabolism of myocardium as influenced by fatty acids and epinephrine.
- Accumulation of nonesterified fatty acids in ischemic canine myocardium.
- Adenine nucleotide transport during cardiac ischemia.
Cited by
- Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion.
- Mildronate, a Novel Fatty Acid Oxidation Inhibitor and Antianginal Agent, Reduces Myocardial Infarct Size Without Affecting Hemodynamics
- Effects of L-carnitine on mechanical recovery of isolated rat hearts in relation to the perfusion with glucose and palmitate
- Modulation of hSlo BK current inactivation by fatty acid esters of CoA
- Mitochondrial function in the oxygen depleted and reoxygenated myocardial cell.
- Effect of D,L‐carnitine on the response of the isolated heart of the rat to ischaemia and reperfusion: relation to mitochondrial function
- The metabolic effect of carbon monoxide on the heart
- Metabolic functions of L-carnitine and its effects as feed additive in horses. A review.
- Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion.
- Enhanced effect of gap junction uncouplers on macroscopic electrical properties of reperfused myocardium
- Adenine nucleotide translocase in the focus of cardiovascular diseases.
- Cardiac ionic currents and acute ischemia: from channels to arrhythmias.
- Einfluss von L-Carnitin auf das Herz - Ein Mikronährstoff mit hämodynamischen und energetischen Wirkungen auf das isolierte Langendorff-Herz
- Mitochondrial injury in the ischemic-reoxygenated cardiomyocyte: the role of lipids and other pathogenic factors
- Irreversible ischemic injury — definition of the problem
- Severe ischemic injury and the oxygen paradox
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