High levels of human apolipoprotein A-I and high density lipoproteins in transgenic mice do not enhance efflux of cholesterol from a depot of injected lipoproteins. Relevance to regression of atherosclerosis?
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Summary
It appears, therefore, that while an increase above physiological levels of apo A-I or plasma HDL does play a pivotal role in the prevention of initiation and progression of early stages of atherosclerosis, the effectiveness of such an increase for the regression stage remains still to be demonstrated.
- Type
- article
- Published
- 1999-06-01
- Cited by
- 22
- References
- 45
- OpenAlex
- https://openalex.org/W43488450
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:867570
Keywords
Cholesterol, Endocrinology, Apolipoprotein B, Internal medicine, Efflux
References
- Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs.
- A comparative study on the removal of cellular lipids from Landschütz ascites cells by human plasma apolipoproteins.
- High density lipoprotein metabolism.
- Molecular physiology of reverse cholesterol transport.
- Dexamethasone impairs cholesterol egress from a localized lipoprotein depot in vivo.
- The role of apolipoprotein A-IV in reverse cholesterol transport studied with cultured cells and liposomes derived from an ether analog of phosphatidylcholine.
- Role of apolipoproteins in cellular cholesterol efflux.
- Comparison of cholesterol egress from cultured cells enriched with cholesterol ester after exposure to cationized LDL or to LDL and chloroquine.
- Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
- Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV
- Cholesterol efflux in vivo from a depot of cationized LDL injected into a thigh muscle of small rodents.
- Lipoprotein lipase in heart cell cultures is suppressed by bacterial lipopolysaccharide: an effect mediated by production of tumor necrosis factor.
- Solubility in aqueous solutions of ethanol of the small molecular weight peptides of the serum very low density and high density lipoproteins: relevance to the recovery problem during delipidation of serum lipoproteins.
- High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase
- Kinetic parameters for high density lipoprotein apoprotein AI and cholesteryl ester transport in the hamster.
- Reverse cholesterol transport--a review of the process and its clinical implications.
- Metabolism of HDL-cholesteryl ester in the rat, studied with a nonhydrolyzable analog, cholesteryl linoleyl ether.
- Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
- Cholesterol efflux, lecithin-cholesterol acyltransferase activity, and pre-beta particle formation by serum from human apolipoprotein A-I and apolipoprotein A-I/apolipoprotein A-II transgenic mice consistent with the latter being less effective for reverse cholesterol transport.
- Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice.
Cited by
- High-density lipoprotein heterogeneity and function in reverse cholesterol transport
- Low High-Density Lipoprotein Cholesterol
- Clearance of cationized LDL cholesterol from a muscle depot is not enhanced in human apolipoprotein A-IV transgenic mice.
- Macrophage Cholesterol Metabolism, Apolipoprotein E, and Scavenger Receptor AI/II mRNA in Atherosclerosis-Susceptible and -Resistant Mice
- Can Atherosclerosis Regress?
- Antiatherogenic role of high-density lipoproteins: insights from genetically engineered-mice.
- High-density lipoproteins and atherosclerosis.
- Dynamics of reverse cholesterol transport: protection against atherosclerosis.
- Intravenous apoA-I/lecithin discs increase pre-beta-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans.
- Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo.
- Overexpression of Apolipoprotein A-I Promotes Reverse Transport of Cholesterol From Macrophages to Feces In Vivo
- Atheroprotective mechanisms of HDL.
- Inflammation and skin cholesterol in LDLr−/−, apoA-I−/− mice: link between cholesterol homeostasis and self-tolerance? Published, JLR Papers in Press, October 28, 2006.
- Novel in vivo Method for Measuring Cholesterol Mass Flux in Peripheral Macrophages
- Effect of atherogenic diet on reverse cholesterol transport in vivo in atherosclerosis susceptible (C57BL/6) and resistant (C3H) mice.
- Estudio de las propiedades antiaterogénicas de las HDL de ratones transgénicos de apoA-II humana
- HDL AND REVERSE CHOLESTEROL TRANSPORT IN HUMANS AND ANIMALS: LESSONS FROM PRE-CLINICAL MODELS AND CLINICAL STUDIES.
- Autres dyslipidémies génétiques
- The Role of the Vascular Extracellular Matrix and the Age-Related Changes of Arteries
- Avaluació del Transport Revers de Colesterol Específic de Macròfags
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