Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.
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Summary
Genotype-phenotype comparisons demonstrated a codominant type of inheritance by a gene-dose effect: samples with two active alleles expressed a statistically significant higher enzymatic activity compared to those with one null allele (P < 0.0001, ANOVA).
- Type
- article
- Published
- 2000-08-01
- Cited by
- 187
- References
- 29
- OpenAlex
- https://openalex.org/W41436476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33484269
Keywords
Biology, Genotyping, Genotype, Genetics, Allele
References
- Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.
- An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences.
- Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene
- A comparative investigation of the metabolism of methyl bromide and methyl iodide in human erythrocytes
- Glutathione transferase activity and formation of macromolecular adducts in two cases of acute methyl bromide poisoning.
- Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.
- Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes.
- Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.
- Comparative genotyping and phenotyping of glutathione S-transferase GSTT1
- Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility.
- Characterization of the Human Class Mu GlutathioneS-Transferase Gene Cluster and the GSTM1Deletion*
- Detection of the GSTM1*0 allele by long polymerase chain reaction.
- Glutathione‐S‐transferase polymorphisms and risk of squamous‐cell carcinoma of the head and neck
- The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
- Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset.
- A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
- Effects of glutathione transferase theta polymorphism on the risk estimates of dichloromethane to humans.
- Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in a Swedish population.
- Concordance between enzyme activity and genotype of glutathione S-transferase theta (GSTT1).
- Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity.
Cited by
- Oxidative stress, human genetic variation, and disease.
- Fine-scale structural variation of the human genome
- Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment
- Risk factors for developing de novo autoimmune hepatitis associated with anti–glutathione S‐transferase T1 antibodies after liver transplantation
- Genes de enzimas de biotransformação e fissuras labio-palatinas em humanos : um estudo da interação genético-ambiental
- Genetic Variation and its Role in Malignancy
- Polimorfismos dos genes do citocromo P450, da glutationa S-transferase e do supressor de tumor TP53 em populações sul-americanas e em pacientes com doença pulmonar obstrutiva crônica e câncer de pulmão
- IDENTIFICATION OF GENETIC POLYMORPHISMS ASSOCIATED WITH OESOPHAGEAL SQUAMOUS CELL CARCINOMA RISK IN SOUTH AFRICA
- Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs.
- Genetic Variation - Effect on the Risk of Cancers of Lung and Oropharynx
- Fruits and vegetables, detoxification genes and intermediate endpoints in colorectal cancer prevention
- Development of new method of primer design based on Genomewide for SNP typing under problem solving environment on grid
- Análise dos polimorfismos GSTM1 e GSTT1 em pacientes que desenvolveram leucemias agudas
- Multiplex PCR detection of GSTM1, GSTT1, and GSTP1 gene variants: simultaneously detecting GSTM1 and GSTT1 gene copy number and the allelic status of the GSTP1 Ile105Val genetic variant.
- Meta-Analysis-Based Preliminary Exploration of the Connection between ATDILI and Schizophrenia by GSTM1/T1 Gene Polymorphisms
- Gene–environment interactions in esophageal cancer
- Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma
- Glutathione transferases, regulators of cellular metabolism and physiology.
- Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression.
- NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure--a literature review.
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