The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
Explore this paper's citation graph
Summary
The biochemical functions of GST are described to show how individual isoenzymes contribute to resistance to carcinogens, antitumor drugs, environmental pollutants, and products of oxidative stress, and to allow identification of factors that may modulate resistance to specific noxious chemicals.
- Type
- review
- Published
- 1995-01-01
- Cited by
- 3,603
- References
- 724
- OpenAlex
- https://openalex.org/W2046750894
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6998003
Keywords
Isozyme, Biology, Glutathione S-transferase, Biochemistry, Gene
References
- Structural and functional studies of ligandin, a major renal organic anion-binding protein.
- Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.
- The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione.
- Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene.
- Positive and negative regulatory elements in the mouse albumin enhancer.
- Glutathione S-transferase subunits in the mouse and their catalytic activities towards reactive electrophiles.
- Differential activation and inhibition of different forms of rat liver glutathione S-transferase by the herbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T).
- The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression
- Participation of the phenolic hydroxyl group of Tyr-8 in the catalytic mechanism of human glutathione transferase P1-1.
- Reversibility in glutathione-conjugate formation.
- Role of pars nervosa of the hypophysis in amphibian water economy: a re-assessment.
- Photoaffinity labeling of Arabidopsis thaliana plasma membrane vesicles by 5-azido-[7-3H]indole-3-acetic acid: identification of a glutathione S-transferase.
- Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes.
- Isolation of a mouse theta glutathione S-transferase active with methylene chloride.
- Plant phenols as in vitro inhibitors of glutathione S-transferase(s).
- Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase.
- Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver.
- Glutathione S-transferase in yeast: induction of mRNA, cDNA cloning and expression in Escherichia coli.
- Glutathione S-transferases: biomedical applications.
- Mass spectrometric analysis of rat liver cytosolic glutathione S-transferases: modifications are limited to N-terminal processing.
Cited by
- Identification et étude de l'expression de gènes de détoxication chez les bivalves d'eau douce Unio tumidus et Corbicula fluminea : approches en laboratoire et en milieu naturel
- Glutathione S-transferase isoenzyme profile in non-tumor and tumor human kidney tissue
- Primary peritoneal low-grade serous carcinoma forming a mass in the colon mimicking a colonic primary carcinoma: a case report.
- Stratégie de vectorisation d'acides nucléiques et de drogues anticancéreuses dans les cellules hépatiques en culture
- LOSS OF TRPML1 ALTERS CELLULAR FUNCTIONS OUTSIDE OF THE LYSOSOME: DISSECTING THE RELATIONSHIP BETWEEN LYSOSOMAL AND MITOCHONDRIAL HEALTH IN MLIV
- Glutathione and related enzymes in multidrug resistance.
- Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells.
- Rationale for Reclassification of a Distinctive Subdivision of Mammalian Class Mu Glutathione S-Transferases That Are Primarily Expressed in Testis*
- Purification and characterization of a novel alpha-class glutathione transferase from human liver.
- Protection by protein A of apoptotic cell death caused by anti-AIDS drug zidovudine.
- The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
- Polymorphism in the Glutathione S‐transferase P1 Gene and Risk for Preeclampsia
- Human glutathione-S-transferase: cloning and expression in Lactococcus lactis.
- AN9, a petunia glutathione S-transferase required for anthocyanin sequestration, is a flavonoid-binding protein.
- Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans.
- Oxidative stress, human genetic variation, and disease.
- Glutathione‐associated enzymes in head and neck squamous cell carcinoma and response to cisplatin‐based neoadjuvant chemotherapy
- Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns.
- Direct selection for paraquat resistance in Drosophila results in a different extended longevity phenotype.
- Glutathione transferase isoenzymes from frog (Xenopus laevis) liver and embryo.
Related papers
- Xenobiotics: An Essential Precursor for Living System
- Role of Xenobiotics and its Biodegradation
- AMP deaminase isozymes in human tissues.
- Superoxide dismutase isozymes in different human tissues, their genetic control and intracellular localization.
- Biomonitoring of carcinogenic xenobiotics
- Chloroform-induced alteration of glutathione S-transferase activity.
- The relationship between reduced glutathione level and glutathione S-transferase activity in sheep erythrocytes.
- Glutathione S-transferase isozymes in rat lens.