Cloned T-cell lines with specific cytolytic activity.
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Summary
The search for hybrids derived from somatic crosses between specific cytolytic T-cells (CTL) and cell lines, which express the specific activity of the parental lymphocytes in many laboratories has, sofar, not been successful.
- Type
- article
- Published
- 1978-01-01
- Cited by
- 131
- References
- 7
- OpenAlex
- https://openalex.org/W109672262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33939207
Keywords
CTL*, Cytolysis, Biology, Somatic cell, Cell biology
References
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- Continuously proliferating allospecific T cells, lifespan and antigen receptors
- Cell‐mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse
- Long term culture of tumour-specific cytotoxic T cells
- In Vitro Secondary MLR
Cited by
- Mechanism of T cell activation I. A screening of “step one” ligands
- MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
- Continuous cytotoxic T-cell lines.
- T-cell growth factor and the culture of cloned functional T cells.
- In vivo administration of interleukin-2.
- Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells.
- Short-term culture of spleen lymphocytes for chromosome analysis of small rodents
- The Pharmacology of Lymphocytes
- The differential effects of distinct cytolysis-inhibiting monoclonal antibodies on growth and on cytolytic activity of T cell clones.
- Alloreactive T cell clones.
- Specificity of the T cell receptor for antigen.
- In vitro growth of murine T cells. IV. Use of T-cell growth factor to clone lymphoid cells.
- Recombinant interleukin 2 toxicity, pharmacokinetics, and immunomodulatory effects in a phase I trial.
- Cytolytic T lymphocyte responses to metabolically inactivated stimulator cell. I. Metabolic inactivation impairs both CD and LD antigen signals.
- Surface receptors on lymphoreticular cells: sensory devices for host recognition of foreign antigens and neoplasia.
- Cytolytic T lymphocyte responses to metabolically inactivated stimulator cells. II. Effect of a soluble "costimulator" factor(s) in primary and secondary mixed leukocyte culture.
- The LAV/HTLV-III virus may evade elimination by the immune system by inducing low zone tolerance to itself.
- An unusual clonotypic determinant on a cytotoxic T lymphocyte line is encoded by an immunoglobulin heavy chain variable region gene.
- Production of T Cell Clones
- Antigenic tumor cell variants obtained with mutagens.
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