Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines

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Summary

Analysis of RNA-seq data encoding TMPRSS6 isoforms and other proteins involved in hepcidin production uncovered significant differences in expression levels between hepatocellular carcinoma (HCC) cell lines and normal human liver samples, providing important information about commonly used liver cell models and shed light on the impact of two TMPR SS6 mutations associated with IRIDA.

Type
article
Published
2018-08-22
Cited by
15
References
54
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Open access

Keywords

Physics

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