The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
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Summary
Findings provide a biochemical basis for hepcidin control by HFE, TfR2, and HJV in the central nervous system through the BMP-SMAD signaling pathway.
- Type
- article
- Published
- 2012-11-01
- Cited by
- 204
- References
- 59
- OpenAlex
- https://openalex.org/W2027090078
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1276264
Keywords
Hepcidin, SMAD, Immunoprecipitation, Hereditary hemochromatosis, Cell biology
References
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- Molecular Evolution of Hemojuvelin and the Repulsive Guidance Molecule Family
- Lack of the bone morphogenetic protein BMP6 induces massive iron overload
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- Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing*
- Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
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- Huh‐7: A human “hemochromatotic” cell line
- A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
- Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2
- Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome.
- Regulation of expression of murine transferrin receptor 2.
- BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism
Cited by
- The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.
- The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body
- Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines
- Transferrin Saturation Inversely Correlates with Platelet Function
- Modulation of hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches
- Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells.
- A Computational Model of Human Iron Metabolism
- Nadmierne gromadzenie żelaza w organizmie - realne zagrożenie dla zdrowia człowieka?
- Hepcidin and Host Defense against Infectious Diseases
- Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation*
- Molecular basis of HFE-hemochromatosis
- Iron storage disease in Asia‐Pacific populations: The importance of non‐HFE mutations
- Iron homeostasis and its disruption in mouse lung in iron deficiency and overload
- The soluble form of HFE protein regulates hephaestin mRNA expression in the duodenum through an endocytosis-dependent mechanism.
- Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in HFE hemochromatosis
- HFE-Related Hemochromatosis: An Update for the Rheumatologist
- Iron and Diabetes Risk
- Iron regulation by hepcidin.
- Insufficient Referral for Genetic Counseling in the Management of Hereditary Haemochromatosis in Portugal: A Study of Perceptions of Health Professionals Requesting HFE Genotyping
- The extrahepatic role of TFR2 in iron homeostasis
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