Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
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Summary
These data reveal that, to protect its genomic and functional integrity, the hematopoietic system critically depends on the combined activities of repair and replication of helix-distorting oxidative nucleotide lesions by ggNER and Rev1-dependent TLS, respectively.
- Type
- article
- Published
- 2017-09-28
- Cited by
- 36
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2749473676
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206951638
Keywords
Haematopoiesis, DNA damage, Biology, DNA, Mitochondrial DNA
References
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Cited by
- DNA repair fidelity in stem cell maintenance, health, and disease
- Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
- Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells
- 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
- Role of Y-family Translesion DNA Polymerases in Replication Stress: Implications for New Cancer Therapeutic Targets
- DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy
- REV1-POL ζ Inhibition and Cancer Therapy.
- Mutagenic replication: target for tumor therapy?
- Sml1 Inhibits the DNA Repair Activity of Rev1 in Saccharomyces cerevisiae during Oxidative Stress
- The in vivo role of Rev1 in mutagenesis and carcinogenesis
- Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia
- Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profiles
- Autophagy‐Sirt3 axis decelerates hematopoietic aging
- Nucleotide Excision Repair, XPA-1, and Translesion Synthesis Complex, POLZ-1 and REV-1, are Critical for Interstrand Crosslink Repair in C. elegans Germ Cells
- Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
- Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways
- Folate Intake Alters Mutation Frequency and Profiles in a Tissue- and Dose-Specific Manner in MutaMouse Male Mice.
- Pediatric MDS and Bone Marrow Failure-Associated Germline Mutations in SAMD9 and SAMD9L Impair Multiple Pathways in Primary Hematopoietic Cells
- Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia
- TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure
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