Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm.
Explore this paper's citation graph
Summary
Although there has been significant progress in the development of potential therapeutics, more studies are needed to establish clear mechanisms of action and target specificity in order to transition from animal models to the assessment of safety and use in humans.
- Type
- article
- Published
- 2017-01-01
- Cited by
- 50
- References
- 276
- OpenAlex
- https://openalex.org/W27546056
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8469340
Keywords
Political science, Humanities, Philosophy
References
- Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells.
- Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials
- Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice
- Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy.
- Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis*
- Amyotrophic Lateral Sclerosis: New Perpectives and Update
- Transactivation of Trk receptors in spinal motor neurons.
- Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?
- Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study.
- Reduced Levels of Brain Derived Neurotrophic Factor (BDNF) in the Serum of Diabetic Retinopathy Patients and in the Retina of Diabetic Rats
- The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve.
- Decreased Phosphorylation Levels of TrkB Neurotrophin Receptor in the Spinal Cords from Patients with Amyotrophic Lateral Sclerosis
- Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration.
- Chronic Inhibitory Effect of Riluzole on Trophic Factor Production
- Pharmacological approaches to retinitis pigmentosa: A laboratory perspective.
- How do C9ORF72 repeat expansions cause ALS and FTD: can we learn from other non-coding repeat expansion disorders?
- Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents.
- Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve.
- The prevalence of Parkinson's disease: A systematic review and meta‐analysis
- Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells
Cited by
- The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS
- Neuronal plasticity and neurotrophic factors in drug responses
- Is the Eye an Extension of the Brain in Central Nervous System Disease?
- Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain
- Immobilization of Neurotrophin Peptides on Gold Nanoparticles by Direct and Lipid-Mediated Interaction: A New Multipotential Therapeutic Nanoplatform for CNS Disorders
- Estrogen receptor‐β of microglia underlies sexual differentiation of neuronal protection via ginsenosides in mice brain
- Neurotrophin‐3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease
- Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection
- Targeting neurotrophin signaling in cancer: The renaissance
- Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
- The Copper(II)-Assisted Connection between NGF and BDNF by Means of Nerve Growth Factor-Mimicking Short Peptides
- Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity.
- Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
- Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss
- Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease
- Neuronal activity enhances Brain-Derived Neurotrophic Factor local signaling in axon through modifying its axonal transport
- Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors
- Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFRα1
- Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri
Related papers
No related papers recorded.