The Copper(II)-Assisted Connection between NGF and BDNF by Means of Nerve Growth Factor-Mimicking Short Peptides
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Summary
D-NGF(1-15) interacts with the TrkA-D5 domain and induces the activation of its signaling pathways, and the signaling cascade induced by the NGF peptides ultimately involves cAMP response element-binding protein (CREB) activation and an increase in BDNF protein level, in keeping with the previous result showing an increase of BDNF mRNA.
- Type
- article
- Published
- 2019-04-01
- Cited by
- 35
- References
- 93
- Access
- Open access
- OpenAlex
- https://openalex.org/W2934774093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:92998379
Keywords
Nerve growth factor, Tropomyosin receptor kinase A, Neurotrophin, CREB, Cell biology
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Cited by
- Greater Circulating Copper Concentrations and Copper/Zinc Ratios are Associated with Lower Psychological Distress, But Not Cognitive Performance, in a Sample of Australian Older Adults
- Nerve growth factor catches copper in neuronal inning
- The curious case of opossum prion: a physicochemical study on copper(ii) binding to the bis-decarepeat fragment from the protein N-terminal domain.
- Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β‐Amyloid Toxicity
- hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay
- Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro
- Distribution in the brain and possible neuroprotective effects of intranasally delivered multi-walled carbon nanotubes
- Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications
- Drug delivery platforms for neonatal brain injury.
- Metal ion coordination in peptide fragments of neurotrophins: A crucial step for understanding the role and signaling of these proteins in the brain
- Interaction of Serum Copper and Neurometabolites on Executive Dysfunction in Unmedicated Patients With Major Depressive Disorder
- Nerve Growth Factor Peptides Bind Copper(II) with High Affinity: A Thermodynamic Approach to Unveil Overlooked Neurotrophin Roles
- Peptides Derived from Growth Factors to Treat Alzheimer’s Disease
- Relevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studies
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- Computational Insights into the Sequence-Activity Relationships of the NGF(1–14) Peptide by Molecular Dynamics Simulations
- Neurotrophic Activity and Its Modulation by Zinc Ion of a Dimeric Peptide Mimicking the Brain-Derived Neurotrophic Factor N-Terminal Region
- Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements.
- Bioinspired Nanoplatforms Based on Graphene Oxide and Neurotrophin-Mimicking Peptides
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