Mitochondria Biogenesis Modulates Iron–Sulfur Cluster Synthesis to Increase Cellular Iron Uptake
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Summary
Under enhanced mitochondria biogenesis, increased Fe-S cluster synthesis inhibits the function of iron-regulating protein (IRP)1 and hence stimulates the expression of 5′-aminolevulinate synthase 2 (ALAS2), a target of IRP1 and rate-limiting enzyme in erythroid heme biogenesis.
- Type
- article
- Published
- 2020-04-13
- Cited by
- 11
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W3015303357
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:215758823
Keywords
Biogenesis, Mitochondrial biogenesis, Transferrin receptor, Biology, Mitochondrion
References
- Sideroblastic anemia: diagnosis and management.
- Mammalian iron–sulphur proteins: novel insights into biogenesis and function
- Metabolic control through the PGC-1 family of transcription coactivators.
- Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.
- Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.
- Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice
- Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase
- PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
- N- and C-terminal Transactivation Domains of GATA1 Protein Coordinate Hematopoietic Program*
- Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
- Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides
- Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
- Translational Control by Heme-Regulated eIF2α Kinase during Erythropoiesis
- An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis
- Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation
- - thalassemia : a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
- Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.
- The physiological functions of iron regulatory proteins in iron homeostasis - an update
- PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis
- Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.
Cited by
- The Role of Iron in Benign and Malignant Hematopoiesis
- Expression profile analysis reveals hub genes that are associated with immune system dysregulation in primary myelofibrosis
- ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation.
- Effect of maternal lactoferrin supplementation on iron contents and anti-oxidant capacity in Dahe black Pig neonates
- Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
- Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation
- Molecular Mechanisms of Iron Transport and Homeostasis Regulated by Antarctic Krill-Derived Heptapeptide-Iron Complex.
- Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity
- Lactoferrin on Physiological Characteristics and Intestinal Microorganisms in Anemic Rats
- Identification of Key Genes in Systemic Lupus Erythematosus through integrated bioinformatics
- Targeting TREM2 to disrupt the mitochondrial lipid and iron metabolism in cisplatin-resistant gastric cancer cells
- The functional study of core genes in systemic lupus erythematosus obtained through WGCNA analysis and two- sample Mendelian randomization research
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