A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling
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Summary
The products of multi-exon genes are a mixture of alternatively spliced isoforms, from which the translated proteins can have similar, different or even opposing functions, and it is essential to differentiate and annotate functions for individual isoforms.
- Type
- article
- Published
- 2016-01-06
- Cited by
- 6
- References
- 82
- Access
- Open access
- OpenAlex
- https://openalex.org/W26740460
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2381126
Keywords
Art
References
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- Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels*
- Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
- Tissue-based map of the human proteome
- Predicting Functional Alternative Splicing by Measuring RNA Selection Pressure from Multigenome Alignments
- Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes
Cited by
- Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project
- Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources
- ASV-ID, a Proteogenomic Workflow To Predict Candidate Protein Isoforms on the Basis of Transcript Evidence.
- DIFFUSE: predicting isoform functions from sequences and expression profiles via deep learning
- Machine learning tools for mRNA isoform function prediction
- DeepRetention: A Deep Learning Approach for Intron Retention Detection
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