Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
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Summary
It is estimated that transcripts from ∼95% of multiexon genes undergoAlternative splicing and that there are ∼100,000 intermediate- to high-abundance alternative splicing events in major human tissues.
- Type
- article
- Published
- 2008-11-02
- Cited by
- 3,914
- References
- 22
- OpenAlex
- https://openalex.org/W2011920499
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9228930
Keywords
Biology, Alternative splicing, RNA splicing, Exon, splice
References
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- Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach
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- A computer program for aligning a cDNA sequence with a genomic DNA sequence.
- Mapping and quantifying mammalian transcriptomes by RNA-Seq
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- Molecular diversity of myofibrillar proteins: gene regulation and functional significance.
- Categorical Data Analysis
Cited by
- Genome-wide Characterization of RNA Expression and Processing
- Expression and functions of the star proteins Sam68 and T-STAR in mammalian spermatogenesis.
- Designing, performing, and interpreting a microarray-based gene expression study.
- Alternative splicing of tumor suppressors and oncogenes.
- Cancer-associated regulation of alternative splicing
- Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses
- Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway*
- FusionSeq: a modular framework for finding gene fusions by analyzing paired-end RNA-sequencing data
- Genetics of Gene Expression in CNS
- Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples
- Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration
- Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase.
- The cyclin L homolog MOS12 and the MOS4-associated complex are required for the proper splicing of plant resistance genes.
- A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis
- Genome-wide activation of latent donor splice sites in stress and disease
- Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport
- Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks.
- Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance
- DeconRNASeq: a statistical framework for deconvolution of heterogeneous tissue samples based on mRNA-Seq data
- Signaling from depolarization to alternative splicing: Identification of molecular links mediating inducible exon skipping
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