Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels*
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Summary
TRPM3ΔICF variants are regulatory channel subunits fine-tuning TRPM3 channel activity, and coexpression of ΔICF proteins with functional TR PM3 subunits not only reduced the number of channels but also impaired TRPM 3-mediated Ca2+ entry.
- Type
- article
- Published
- 2012-09-07
- Cited by
- 67
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1995232179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8181953
Keywords
Transient receptor potential channel, Alternative splicing, Ion channel, Cell biology, Ionotropic effect
References
- TRPM3 is expressed in sphingosine‐responsive myelinating oligodendrocytes
- The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.
- TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells
- Calcium Plays a Critical Role in Determining the Acetylcholine Receptor-clustering Activities of Alternatively Spliced Isoforms of Agrin*
- An Alternative Splicing Product of the Murine trpv1 Gene Dominant Negatively Modulates the Activity of TRPV1 Channels*
- TRPM3 is a nociceptor channel involved in the detection of noxious heat.
- Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction
- Characterisation of TRPM8 as a pharmacophore receptor.
- A generic method for assignment of reliability scores applied to solvent accessibility predictions
- Protein structure prediction servers at University College London
- Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells
- Function of alternative splicing.
- TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes*
- Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5.
- Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
- The leucine-rich repeat structure
- Phenotype of a recombinant store‐operated channel: highly selective permeation of Ca2+
- Transient Receptor Potential Melastatin 1 (TRPM1) Is an Ion-conducting Plasma Membrane Channel Inhibited by Zinc Ions*
- Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors.
- Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels*
Cited by
- A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling
- TRPM3 Expression in Mouse Retina
- Riluzole activates TRPC5 channels independently of PLC activity
- Alternative Splicing of G-protein Coupled Receptors: Relevance to Pain Management
- Systematically Differentiating Functions for Alternatively Spliced Isoforms through Integrating RNA-seq Data
- Permeation, regulation and control of expression of TRP channels by trace metal ions
- Clemizole Hydrochloride Is a Novel and Potent Inhibitor of Transient Receptor Potential Channel TRPC5
- Erratum to: Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels
- Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model
- Trafficking of ThermoTRP Channels
- Contribution of calcium-conducting channels to the transport of zinc ions
- Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels
- Signal transduction via TRPM3 channels in pancreatic β-cells.
- Overexpression of short TRPM8 variant α promotes cell migration and invasion, and decreases starvation-induced apoptosis in prostate cancer LNCaP cells.
- Flavanones That Selectively Inhibit TRPM3 Attenuate Thermal Nociception In Vivo
- Apomorphine Is a Bimodal Modulator of TRPA1 Channels
- Mutation of the Melastatin-Related Cation Channel, TRPM3, Underlies Inherited Cataract and Glaucoma
- Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel
- Recent advances in therapeutic strategies that focus on the regulation of ion channel expression.
- Mechanosensitive ion channels
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