Role of iodide metabolism in physiology and cancer.
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Summary
Alterations in the expression of I- transporters are associated with tumor development in a cancer-type-dependent manner and, accordingly, NIS, CFTR and ANO1 have been proposed as tumor markers.
- Type
- review
- Published
- 2018-04-01
- Cited by
- 91
- References
- 173
- Access
- Open access
- OpenAlex
- https://openalex.org/W2787866238
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46810684
Keywords
Physiology, Cancer, Metabolism, Biology, Medicine
References
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- Origin, structure, and biological activities of peroxidases in human saliva.
- Minireview: thyroid hormone transporters: the knowns and the unknowns.
- Thyroid transcription factors in development, differentiation and disease
- The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.
- Aumento della captazione del radioiodio indotto da selumetinib in pazienti con cancro della tiroide
- Human Genome and Diseases: Review¶The TSH receptor and its role in thyroid disease
- Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment
- Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression.
- The Pendred syndrome gene encodes a chloride-iodide transport protein
- The mammary gland iodide transporter is expressed during lactation and in breast cancer
- Altered ion transport by thyroid epithelia from CFTR−/− pigs suggests mechanisms for hypothyroidism in Cystic Fibrosis
- Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy
- Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.
- The Slc26a4 transporter functions as an electroneutral Cl−/I−/HCO3− exchanger: role of Slc26a4 and Slc26a6 in I− and HCO3− secretion and in regulation of CFTR in the parotid duct
- Plasma inorganic iodide as a homeostatic regulator of thyroid function.
- Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis.
- Susceptibility of Helicobacter pylori and its urease activity to the peroxidase-hydrogen peroxide-thiocyanate antimicrobial system.
- Expression of CFTR in human and bovine thyroid epithelium.
- Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia
Cited by
- A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I- Symporter.
- Thyroid peroxidase as a dual active site enzyme: Focus on biosynthesis, hormonogenesis and thyroid disorders of autoimmunity and cancer.
- Fluoride Exposure Induces Inhibition of Sodium/Iodide Symporter (NIS) Contributing to Impaired Iodine Absorption and Iodine Deficiency: Molecular Mechanisms of Inhibition and Implications for Public Health
- The nutrition of iodine in Spain. Needs for the future.
- Iodine Status in the Colombian Population and the Impact of Universal Salt Iodization: A Double-Edged Sword?
- DNA methylation in thyroid cancer.
- Microbiota and Thyroid Interaction in Health and Disease.
- Iodine Bonded with Milk Protein Inhibits Benign Prostatic Hyperplasia Development in Rats.
- Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro.
- Novel therapeutic options for radioiodine-refractory thyroid cancer: redifferentiation and beyond.
- Iodine contents in conventional ultra-high temperature (UHT) processed cow milk: Changes over the year and regional differences. Implications for epidemiological studies on iodine nutritional status.
- Impaired Gene Expression Due to Iodine Excess in the Development and Differentiation of Endoderm and Thyroid Is Associated with Epigenetic Changes
- Expression of pendrin and NIS iodide transporters in human breast tumor and peri-tumoral tissue
- Iodine nutrition in Spain: Future requirements
- Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)
- A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China
- Breast cancer risk among women exposed to fallout after the Chernobyl accident.
- Genetic and Physiological Factors Affecting Human Milk Production and Composition
- Dietary Saccharina japonica is a natural and effective tool to fortify marine teleost black sea bream fillets with iodine: effects on growth, flesh quality, and serum thyroid hormones
- Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?
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