The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways
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Summary
Investigating PCD induced by DFNA5, a gene responsible for autosomal dominant hearing loss and a tumor suppressor gene involved in frequent forms of cancer, shows a down-regulation of protein sorting- and folding-related mechanisms suggesting an additional role for the endoplasmic reticulum (ER).
- Type
- article
- Published
- 2015-07-16
- Cited by
- 52
- References
- 106
- Access
- Open access
- OpenAlex
- https://openalex.org/W26236191
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14337597
Keywords
George (robot), Art, Humanities, Art history
References
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- Uncoupling Protein 2 Negatively Regulates Mitochondrial Reactive Oxygen Species Generation and Induces Phosphatase-Mediated Anti-Inflammatory Response in Experimental Visceral Leishmaniasis
- A DFNA5 Mutation Identified in Japanese Families with Autosomal Dominant Hereditary Hearing Loss
- Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.
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- Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking.
- Cytochrome c oxidase isoform IV‐2 is involved in 3‐nitropropionic acid‐induced toxicity in striatal astrocytes
- Familial Progressive Sensorineural Deafness Is Mainly Due to the mtDNA A1555G Mutation and Is Enhanced by Treatment with Aminoglycosides
- The role of protein quality control in mitochondrial protein homeostasis under oxidative stress
- Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
- A Novel Mutation Identified in the DFNA5 Gene in a Dutch Family: A Clinical and Genetic Evaluation
- Mitochondria, oxygen free radicals, disease and ageing.
Cited by
- Role of DFNA5 in hearing loss and cancer – a comment on Rakusic et al
- An integrated linkage map reveals candidate genes underlying adaptive variation in Chinook salmon (Oncorhynchus tshawytscha)
- External and internal triggers of cell death in yeast
- Pore-forming activity and structural autoinhibition of the gasdermin family
- Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions.
- A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus
- DFNA5 promoter methylation a marker for breast tumorigenesis
- ‘Hints' in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death
- Genetics of Tinnitus: Still in its Infancy
- Proteolytic control of regulated necrosis.
- Noonan Syndrome: An Underestimated Cause of Severe to Profound Sensorineural Hearing Impairment. Which Clues to Suspect the Diagnosis?
- Exonic mutations and exon skipping: lessons learned from DFNA5
- Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer
- Further evidence for “gain-of-function” mechanism of DFNA5 related hearing loss
- Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.
- Association of DFNA5, SYK, and NELL1 variants along with HPV infection in oral cancer among the prolonged tobacco-chewers
- Unraveling the genotypic and phenotypic complexities of genetic hearing loss
- Molecular Aspects of Melatonin Treatment in Tinnitus; a Review.
- Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
- Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model
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