RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38
Explore this paper's citation graph
Summary
Investigation of effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts demonstrated that R ITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITa an interesting tumor-
- Type
- article
- Published
- 2014-07-01
- Cited by
- 61
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2000847178
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17510148
Keywords
Apoptosis, Biology, Programmed cell death, Cell culture, Cell cycle
References
- Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis.
- Transcriptional control of human p53-regulated genes
- AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise?
- Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
- Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
- BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M
- The first 30 years of p53: growing ever more complex
- When mutants gain new powers: news from the mutant p53 field
- MDM2, MDMX and p53 in oncogenesis and cancer therapy
- Ionizing radiation activates c-Jun NH2-terminal kinase (JNK/SAPK) via a PKC-dependent pathway in human thyroid cells.
- Targeting the p53 signaling pathway in cancer therapy - The promises, challenges, and perils
- Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.
- Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma
- Mutations in the P53 Tumor Suppressor Gene in Colorectal Cancer in Taiwan
- Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
- Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells
- Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
- Activation of a unique p53-dependent DNA damage response
- JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species.
- Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors
Cited by
- RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.
- The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain
- p73 regulates basal and starvation-induced liver metabolism in vivo
- TAp73 transcriptionally represses BNIP3 expression
- The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death
- Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer.
- Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells
- DHEA Alleviates Oxidative Stress of Muscle Cells via Activation of Nrf2 Pathway
- p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis.
- CRISPR-Cas9-based target validation for p53-reactivating model compounds
- Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis
- APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts
- p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression
- Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest.
- Metabolic pathways regulated by TAp73 in response to oxidative stress
- P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
- Ultraconserved long non-coding RNA uc.63 in breast cancer
- Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability.
- The role of p53 in cancer drug resistance and targeted chemotherapy
- Exploiting the p53 Pathway for Therapy.
Related papers
- The regulation of MDM2 oncogene and its impact on human cancers
- Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2
- Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways
- Tumor suppression and normal aging in mice with constitutively high p53 activity.
- Mechanism-specific signatures for small-molecule p53 activators
- Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
- MDM2: life without p53.
- S3: Evolution of MDM2 and TP53 status over time of 5 patients affected by MDM2-amplified GBM. from Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas
- Tumor spectrum in ARF-deficient mice.