CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
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Summary
Although the exact role played by CD40 in IgE responses in vivo remains to be established, this T cell-independent system represents a useful model to characterize the biochemical and molecular events leading to IgE synthesis in human B cells.
- Type
- article
- Published
- 1990-12-01
- Cited by
- 447
- References
- 19
- Access
- Open access
- OpenAlex
- https://openalex.org/W1989055057
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8949239
Keywords
Immunoglobulin E, CD23, CD40, Interleukin 4, Monoclonal antibody
References
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- A B‐lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
- Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors.
- Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.
- Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration.
- Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. A study with anti-IgM and anti-CDw40 antibodies.
- A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
- Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.
- Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.
- Regulation of IGE synthesis in man.
- Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production
- IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.
- Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens
- Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome.
- Clonal and molecular characteristics of the human IgE-committed B cell subset
- Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
Cited by
- An adult diagnosed as hyper-IgM immunodeficiency syndrome.
- Allergen-specific IgE production of committed B cells from allergic patients in vitro.
- TH1-TH2 cells in allergic responses: at the limits of a concept.
- Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching
- Identification of differentially expressed genes in CD19+ve B lymphocytes in allergic asthma.
- Selective inhibition of spontaneous IgE and IgG4 production by interleukin-8 in atopic patients.
- Human B lymphocytes: phenotype, proliferation, and differentiation.
- Mechanism and regulation of immunoglobulin isotype switching.
- CD40 Ligand Knockout Mice
- Role of contact and soluble factors in the growth and differentiation of B cells by helper T cells.
- T-Cells in the Pathogenesis of Asthma and Allergic Diseases
- The role of CD40 ligand in human disease.
- Murine animal models to study the central role of T cells in immediate-type hypersensitivity responses.
- Studies of EBV infection of B Lymphocytes ex Vivo and in Vitro
- More or less IgE : therapeutic vaccines, adjuvants and genes and their effect on IgE levels.
- Regulation of interleukin‐6 and interleukin‐6R α (gp80) expression by murine immunoglobulin‐secreting B‐cell hybridomas
- Purification, characterization and immunological studies of rat urinary proteins causing allergy in humans Second edition
- Activation of the Mouse Ig Germline ε Promoter by IL-4 Is Dependent on AP-1 Transcription Factors1
- Molecular processes that regulate class switching.
- The role of T-cell co-stimulatory molecules in murine models of allergic asthma
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