Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer
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Summary
How GPCRs recognize four classes of cancer-relevant lipids and how their dysregulation contributes to tumorigenesis and how they may be therapeutically exploited is discussed.
- Type
- review
- Published
- 2016-08-04
- Cited by
- 21
- References
- 349
- Access
- Open access
- OpenAlex
- https://openalex.org/W2194881309
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27367752
Keywords
Druggability, Biology, G protein-coupled receptor, Cancer, Lipid metabolism
References
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- Identification of Residues Important for Agonist Recognition and Activation in GPR40*
- Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
- Unique Ligand Selectivity of the GPR92/LPA5 Lysophosphatidate Receptor Indicates Role in Human Platelet Activation*
- Sphingosine‐1‐phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival
- A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor*
- Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32.
- The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas
- Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
- PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.
- Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells.
- Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
- Mutagenic Analysis of Platelet Thromboxane Receptor Cysteines
- Characterizing pharmacological ligands to study the long‐chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4
- Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation1
Cited by
- Free Fatty Acid Receptors and Cancer: From Nutrition to Pharmacology.
- Serum lipidomic study reveals potential early biomarkers for predicting response to chemoradiation therapy in advanced rectal cancer: A pilot study
- Multi-OMICS: a critical technical perspective on integrative lipidomics approaches.
- Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor
- Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations.
- GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets
- Entering the Pocket: Crystal Structure of a Prostaglandin D2 Receptor.
- Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes.
- Molecular Mechanisms of Selected Disease-Linked Proteins Studied Through Atomistic Molecular Dynamics Simulations
- Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent
- Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain
- The α‐melanocyte‐stimulating hormone/melanocortin‐1 receptor interaction: A driver of pleiotropic effects beyond pigmentation
- Mapping the molecular architecture required for lipid-binding pockets using a subset of established and orphan GPCRs
- Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
- Photoswitchable Lipids
- The P2 purinoceptors in prostate cancer
- STAT proteins in cancer: orchestration of metabolism
- Development and validation of a sensitive assay for the quantification of arachidonoylcyclopropylamide (ACPA) in cell culture by LC–MS/MS
- From genes to therapy: a lipid Metabolism-Related genetic risk model predicts HCC outcomes and enhances immunotherapy
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