CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties
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Summary
Both CCN proteins play a key role in regulating trophoblast cell differentiation by inducing senescence and enhancing migration properties, and reduced levels of CCN1 and CCN3, as found in early-onset preeclampsia, could contribute to a shift from invasive to proliferative EVTs and may explain their shallow invasion properties in this disease.
- Type
- article
- Published
- 2016-01-08
- Cited by
- 28
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2235816290
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13326674
Keywords
Trophoblast, Cell biology, CYR61, Senescence, Matricellular protein
References
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- Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism
- The Matricellular Protein CCN1/Cyr61 Is a Critical Regulator of Sonic Hedgehog in Pancreatic Carcinogenesis*
- The power and the promise of oncogene-induced senescence markers
- Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1alpha and transforming-growth factor-beta3 in the human trophoblast.
- Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.
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- MR-1 Modulates Proliferation and Migration of Human Hepatoma HepG2 Cells through Myosin Light Chains-2 (MLC2)/Focal Adhesion Kinase (FAK)/Akt Signaling Pathway*
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- Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium.
- Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
- The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway*
- Regulation of human trophoblast migration and invasiveness.
Cited by
- Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling
- Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a.
- Notch: A multi-functional integrating system of microenvironmental signals
- Function and Hormonal Regulation of GATA3 in Human First Trimester Placentation
- Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system
- Tumor necrosis factor‐alpha suppresses the invasion of HTR‐8/SVneo trophoblast cells through microRNA‐145‐5p‐mediated downregulation of Cyr61
- Molecular signatures for CCN1, p21 and p27 in progressive mantle cell lymphoma
- The Regulation of Notch Signaling by Src Kinase and Polyphenolic Compounds
- The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA
- Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells
- Measuring mitochondrial respiration in adherent cells infected with Trypanosoma cruzi Chagas, 1909 using Seahorse extracellular flux analyser.
- Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis
- CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta
- Single cell profiling of Hofbauer cells and fetal brain microglia reveals shared programs and functions
- Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3
- Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis
- Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk.
- Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61 m6A
- CCN1-Mediated Signaling in Placental Villous Tissues after SARS-CoV-2 Infection in Term Pregnant Women: Implications for Dysregulated Angiogenesis
- Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases
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