High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity
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Summary
A screening procedure to search for new antiinfluenza inhibitors from 1,200,000 compounds was developed and identified previously reported as well as new antiInfluenza compounds targeting RdRP activity.
- Type
- article
- Published
- 2010-10-25
- Cited by
- 114
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972072255
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25888595
Keywords
Biology, RNA polymerase, Influenza A virus, Mutation, Virology
References
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Cited by
- Drug Screening for Autophagy Inhibitors Based on the Dissociation of Beclin1-Bcl2 Complex Using BiFC Technique and Mechanism of Eugenol on Anti-Influenza A Virus Activity
- Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses
- Development and applications of single-cycle infectious Influenza A Virus (sciIAV)
- Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.
- New small-molecule drug design strategies for fighting resistant influenza A
- Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication
- Newer influenza antivirals, biotherapeutics and combinations
- Influenza virus-host interactions and their modulation by small molecules
- Influenza Research Database: An integrated bioinformatics resource for influenza research and surveillance
- Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: influenza life-cycle and currently available drugs
- Antiviral strategies against influenza virus: towards new therapeutic approaches
- Structure-based discovery of anti-influenza virus A compounds among medicines.
- New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions
- Nucleozin Targets Cytoplasmic Trafficking of Viral Ribonucleoprotein-Rab11 Complexes in Influenza A Virus Infection
- Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase.
- Stabilization of protein-protein interactions by small molecules.
- T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro
- Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy
- Targeting the host or the virus: Current and novel concepts for antiviral approaches against influenza virus infection
- Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening.
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