Prothymosin α overexpression contributes to the development of pulmonary emphysema
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Summary
It is shown that prothymosin α contributes to the pathogenesis of emphysema by increasing acetylation of histones and nuclear factor-kappaB, particularly upon cigarette smoke exposure, and that exposure to cigarette smoke increases prothyrosin α expression.
- Type
- article
- Published
- 2013-05-21
- Cited by
- 38
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W2038011717
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18808664
Keywords
Pathogenesis, Matrix metalloproteinase, Medicine, Pathology, Cancer research
References
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- Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha.
- Prothymosin-α plays a defensive role in retinal ischemia through necrosis and apoptosis inhibition
- Interleukin-18-induced Human Coronary Artery Smooth Muscle Cell Migration Is Dependent on NF-κB- and AP-1-mediated Matrix Metalloproteinase-9 Expression and Is Inhibited by Atorvastatin*
- Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis
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- A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity.
- Prothymosin alpha interacts with C-terminal domain of histone H1 and dissociates p53-histone H1 complex
- Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells.
- NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages*
- Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
Cited by
- Over‐expression of prothymosin‐α antagonizes TGFβ signalling to promote the development of emphysema
- Animal Models of Chronic Obstructive Pulmonary Disease
- Loss of nuclear prothymosin-α expression is associated with disease progression in human superficial bladder cancer
- Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic SIV infection of rhesus macaques
- Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species.
- Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity
- Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective
- Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer
- Prothymosin Alpha and Immune Responses
- Prothymosin alpha‐deficiency enhances anxiety‐like behaviors and impairs learning/memory functions and neurogenesis
- A Solanum incanum extract (SR-T100) regresses vulvar condyloma acuminatum and induces distinct autophagic and apoptotic responses in different types of HPV-infected cells
- Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
- In vitro immunodetection of prothymosin alpha in normal and pathological conditions.
- Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer
- Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1‐deficient mice
- Gγ7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety.
- Supercharged Proteins and Polypeptides
- Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer
- Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes.
- Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.
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