Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells.
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Summary
It is shown that the BMSC could arrest the degeneration of the murine notochordal NP and contribute to the augmentation of the ECM in the NP by both autonomous differentiation and stimulatory action on endogenous cells.
- Type
- article
- Published
- 2009-11-01
- Cited by
- 149
- References
- 29
- OpenAlex
- https://openalex.org/W19584814
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9741515
Keywords
Computer science
References
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- In Vivo Growth Factor Treatment of Degenerated Intervertebral Discs
- Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- Transplantation of mesenchymal stem cells in a canine disc degeneration model
- Intervertebral Disc Cell–Mediated Mesenchymal Stem Cell Differentiation
- Induction of Intervertebral Disc–Like Cells From Adult Mesenchymal Stem Cells
- Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction
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- Injury‐induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse
- Potential biologic therapies for the intervertebral disc.
- The successful use of fentanyl/fluanisone ('Hypnorm') as an anaesthetic for intracranial surgery in neonatal rats
- Primary culture and phenotyping of murine chondrocytes
- The Notochordal Cell in the Nucleus Pulposus: A Review in the Context of Tissue Engineering
- Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre‐mediated excision
- Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration.
- Activation of rat nucleus pulposus cells by coculture with whole bone marrow cells collected by the perfusion method
- Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
- In Vitro Study on Interaction Between Human Nucleus Pulposus Cells and Mesenchymal Stem Cells Through Paracrine Stimulation
- Differentiation of Mesenchymal Stem Cells Transplanted to a Rabbit Degenerative Disc Model: Potential and Limitations for Stem Cell Therapy in Disc Regeneration
- The Functional Significance of Cell Clusters in the Notochordal Nucleus Pulposus: Survival and Signaling in the Canine Intervertebral Disc
Cited by
- Développement de l'ingénierie tissulaire du disque intervertébral : de la physiopathologie aux modèles animaux
- Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells.
- Effects of different pH and oxygen levels on proliferation and chondrogenic differentiation of human mesenchymal stem cells cultured in hydrogels
- Intervertebral disc regeneration. Studies on stem cell niches and cell transplantation
- Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials
- A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk
- Cryopreserved Mesenchymal Stem Cells Stimulate Regeneration in an Intervertebral Disc
- Degeneration of the intervertebral disc with new approaches for treating low back pain.
- Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment
- Determination of the potential of induced pluripotent stem cells to differentiate into mouse nucleus pulposus cells in vitro.
- Conditioned Medium Derived from Notochordal Cell-Rich Nucleus Pulposus Tissue Stimulates Matrix Production by Canine Nucleus Pulposus Cells and Bone Marrow-Derived Stromal Cells
- Review: unraveling the less explored flocking technology for tissue engineering scaffolds
- Delivering Mesenchymal Stem Cells in Collagen Microsphere Carriers to Rabbit Degenerative Disc: Reduced Risk of Osteophyte Formation
- Evaluation of intervertebral disc regeneration with implantation of bone marrow mesenchymal stem cells (BMSCs) using quantitative T2 mapping: a study in rabbits
- Co-culture of annulus fibrosus cells and bone marrow mesenchymal stem cells.
- Microgel Microenvironment Primes Adipose‐Derived Stem Cells Towards an NP Cells‐Like Phenotype
- Role of Pericellular Matrix in Mesenchymal Stem Cell Deformation during Chondrogenic Differentiation
- Peculiarities of Using Stem Cells for Regeneration of the Bone and Cartilage Tissue
- Cells and Biomaterials for Intervertebral Disc Regeneration
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